All public logs

Combined display of all available logs of Glioblastoma Treatments. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).

• 09:04, 30 March 2024 Lazy talk contribs created page Next-Generation CAR T-Cell Therapy for GBM (Created page with "{{TreatmentInfo |drug_name=Next-Generation CAR T-Cell Therapy for GBM |FDA_approval=In trial phase for GBM; FDA-approved for other cancers |used_for=Recurrent Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase 1 (INCIPIENT trial among others) |common_side_effects=Fevers, altered mental status shortly after infusion, significant but manageable neurotoxicity |OS_without=Median survival for recurrent GBM typically less than one year |OS_with=Not fully established; dr...") Tag: Visual edit: Switched
• 21:51, 29 March 2024 Lazy talk contribs created page Gamma Knife Radiosurgery (Created page with "{{TreatmentInfo |drug_name=Gamma Knife Radiosurgery (GKRS) for GBM |FDA_approval=Yes |used_for=Newly diagnosed Glioblastoma Multiforme (GBM) |clinical_trial_phase=N/A (Established treatment modality) |common_side_effects=Lower compared to traditional GBM treatments, with no significant radiation-induced toxicities reported in recent studies. |OS_without=14-16 months with standard treatment. |OS_with=Comparable to standard treatment, specifics depend on individual patient...")
• 21:35, 29 March 2024 Lazy talk contribs created page Radiation via Monoclonal Antibodies (Created page with "<includeonly> {| class="wikitable" |- ! Property !! Information |- | Drug Name || Radiation via Monoclonal Antibodies |- | FDA Approval || Under research, not yet FDA-approved for general use |- | Used for || Glioblastoma (GBM) and potentially other high-grade glioma tumors |- | Clinical Trial Phase || Various phases, with some treatments in early clinical trials |- | Common Side Effects || Side effects vary depending on the specific monoclonal antibody and radioactive c...")
• 09:14, 29 March 2024 Lazy talk contribs created page Template:PropertyTableFormat (Created page with "{| class="wikitable" ! Property ! Value |- | Drug Name | {{{Has drug name}}} |- | FDA Approval | {{{Has FDA approval}}} |- | Used For | {{{Used for}}} |- | Clinical Trial Phase | {{{Clinical trial phase}}} |- ... | Toxicity Explanation | {{{Toxicity explanation}}} |- | Description | {{{Book text}}} |}")
• 08:59, 29 March 2024 Lazy talk contribs created page Proton Radiation Therapy (Created page with "{{TreatmentInfo |drug_name=Proton Beam Therapy (PBT) |FDA_approval=Yes |used_for=Glioblastoma and other cancers |clinical_trial_phase=Ongoing research and clinical trials |common_side_effects=Radiation dermatitis, temporary alopecia, radiation otitis, radiation necrosis (more prevalent in PBT group) |OS_without=Data varies; traditional radiation therapies offer median OS of around 16-21 months for glioblastoma |OS_with=High-dose PBT showed a median OS of 65.6 months for...")
• 06:05, 29 March 2024 Lazy talk contribs created page Optune (Created page with "{{TreatmentInfo |drug_name=Optune (Optune Gio® for newer version) |FDA_approval=Approved for newly diagnosed glioblastoma in October 2015; ongoing trials for broader applications |used_for=Newly diagnosed glioblastoma, with trials for other cancers ongoing |clinical_trial_phase=Phase 3 (EF-14 Trial); Phase 3 TRIDENT trial ongoing |common_side_effects=Mild to moderate skin irritation beneath transducer arrays, thrombocytopenia, nausea, constipation, vomiting, fatigue, he...")
• 05:34, 29 March 2024 Lazy talk contribs created page Category:Over-the-Counter Drugs and Supplements (Created page with "The treatments discussed above generally require a physician’s cooperation in prescribing them. However, there are a number of agents available over-the-counter that have promising anti-cancer properties, and it is reasonable to believe that these can increase the chances of surviving. Some of these with supporting clinical evidence (e.g., protonpump inhibitors such as Prilosec) have been discussed above. A frequent conflict between patients and their oncologists is th...")
• 20:19, 27 March 2024 Lazy talk contribs deleted page CCNU (lomustine) (content was: " {{TreatmentInfo |drug_name=CCNU (lomustine) |category=Other Chemotherapy and Cancer Drugs |book_text=A report from Germany combined TMZ with CCNU (lomustine), the nitrosourea component of the PCV combination (52). Patients (N=39) received CCNU on day 1 of each 6-week cycle, and TMZ on days 2-6. Eight patients received intensified doses of both drugs, with somewhat better survival res...", and the only contributor was "Lazy" (talk))
• 20:18, 27 March 2024 Lazy talk contribs created page EGFR inhibitors: Iressa, Tarceva, and Erbitux (gefitinib, erlotinib, and (Created page with " {{TreatmentInfo |drug_name=EGFR inhibitors: Iressa, Tarceva, and Erbitux (gefitinib, erlotinib, and |category=Other Chemotherapy and Cancer Drugs |book_text=cetuximab) These three drugs, which have FDA approval for several different types of cancer, have the common feature that they target a growth-signaling channel known as the epidermal growth factor. Overexpression or mutation of EGF receptors is involved in the growth many different kinds of cancer, including more...")
• 20:15, 27 March 2024 Lazy talk contribs created page CCNU (lomustine) (Created page with " {{TreatmentInfo |drug_name=CCNU (lomustine) |category=Other Chemotherapy and Cancer Drugs |book_text=A report from Germany combined TMZ with CCNU (lomustine), the nitrosourea component of the PCV combination (52). Patients (N=39) received CCNU on day 1 of each 6-week cycle, and TMZ on days 2-6. Eight patients received intensified doses of both drugs, with somewhat better survival results (but with substantially increased toxicity). For present purposes, the results of...")
• 20:05, 27 March 2024 Lazy talk contribs created page Chloroquine and Hydroxychloroquine (Created page with " {{TreatmentInfo |drug_name=Chloroquine and Hydroxychloroquine |category=Repurposed Drugs |book_text=In aseries of studies conducted in Mexico City (23, 24, 25) patients received the traditional chemotherapy agent BCNU, with or without a 150 mg daily dose of chloroquine (the equivalent of 250 mg chloroquine phosphate). The results were that patients receiving chloroquine had a median survival time of 25-33 months, while those receiving BCNU alone had a median survival t...")
• 13:56, 27 March 2024 Lazy talk contribs created page Silibinin (an ingredient in Milk Thistle) (Created page with "{{TreatmentInfo |drug_name=Silibinin (Silymarin) |FDA_approval=No |used_for=Liver and biliary disorders, adjunct agent in cancer treatment |clinical_trial_phase=Investigated primarily in hepatitis and cirrhosis; small studies in cancers such as acute lymphoblastic leukemia, prostate cancer, breast cancer, head and neck cancer, and hepatocellular carcinoma |common_side_effects=Few reported; mainly gastrointestinal disturbances |OS_without=Not specified |OS_with=Not specif...")
• 22:04, 26 March 2024 Lazy talk contribs created page MN-166 (Created page with "{{TreatmentInfo |drug_name=MN-166 (Ibudilast) |FDA_approval=Approved in Japan for post-stroke complications and bronchial asthma; in late-stage clinical development for ALS, Progressive MS, DCM in other regions |used_for=Experimental for ALS, Progressive MS, DCM, glioblastoma, CIPN, Long COVID, and substance use disorder |clinical_trial_phase=Phase 3 for ALS and DCM, Phase 3-ready for Progressive MS, Phase 2 for glioblastoma, Long COVID, and substance use disorder |commo...")
• 21:49, 26 March 2024 Lazy talk contribs created page Letrozole (Created page with "{ "drug_name": "Letrozole", "FDA_approval": "Yes, for breast cancer; not FDA-approved for glioblastoma", "used_for": "Investigational use in glioblastoma based on preclinical studies", "clinical_trial_phase": "Preclinical studies and early research for glioblastoma", "common_side_effects": "Hot flashes, joint pain, nausea, fatigue, and risk of osteoporosis", "OS_with": "Not available; research in glioblastoma is still in early stages", "PFS_with": "Not avai...")
• 00:37, 26 March 2024 Lazy talk contribs created page Category:Repurposed Drugs (Created page with "== List of Repurposed Drugs == {{#ask: Category:Nutraceuticals and Herbals |?Has treatment name=Drug Name |?Has Usefulness Rating=Usefulness Rating |?Has Toxicity Level=Toxicity Level |format=table }}")
• 00:28, 26 March 2024 Lazy talk contribs created page MGMT (Created page with "== The role of MGMT == � A significant advance in determining which patients will benefit from Temodar was reported by the same research group that reported the definitive trial combining Temodar with radiation. Tumor specimens from the patients in that trial were tested for the level of activation of a specific gene involved in resistance to alkylating chemotherapy (which includes temozolomide and the nitrosoureas, BCNU, CCNU, and ACNU). More specifically, there is an...")
• 00:27, 26 March 2024 Lazy talk contribs created page Full text (Created page with "== The role of MGMT == � A significant advance in determining which patients will benefit from Temodar was reported by the same research group that reported the definitive trial combining Temodar with radiation. Tumor specimens from the patients in that trial were tested for the level of activation of a specific gene involved in resistance to alkylating chemotherapy (which includes temozolomide and the nitrosoureas, BCNU, CCNU, and ACNU). More specifically, there is an...")
• 19:38, 25 March 2024 Lazy talk contribs created page Property:Usefulness Rating (Created page with "Has type::Number")
• 05:53, 24 March 2024 Lazy talk contribs created page Property:Usefulness rating (Created page with "Has type::Number")
• 05:42, 24 March 2024 Lazy talk contribs created page Category:Highly Useful Treatments (Created page with "==Highly Useful Treatments== This page lists all treatments within the wiki that have been rated with a usefulness of 4 or 5, indicating promising or highly effective options based on current research and clinical trials. {{#ask: Category:Treatment Usefulness rating::4 OR Usefulness rating::5 |?Has treatment name=Name |?Usefulness rating |?Clinical trial phase=Phase |format=table |link=all |headers=show |searchlabel=View more treatments |class=wikitable sort...")
• 05:32, 24 March 2024 Lazy talk contribs created page VT-122 (Created page with "{{TreatmentInfo |drug_name=VT-122 (Propranolol and Etodolac combination) |FDA_approval=No (VT-122 is an investigational combination of repurposed drugs; Propranolol and Etodolac are FDA-approved for other conditions) |used_for=Investigational use in cancer treatment, specifically targeting cachexia in non-small cell lung cancer, hepatocellular carcinoma, and potentially glioblastoma |clinical_trial_phase=Phase 2 (based on ongoing and completed trials for various cancer t...")
• 05:27, 24 March 2024 Lazy talk contribs created page Angiotensin-II Receptor Blockers (ARB) (Created page with "{{TreatmentInfo |drug_name=Angiotensin-II Receptor Blockers (ARB) |FDA_approval=Yes (for hypertension; repurposed for cancer studies) |used_for=Investigational use in glioblastoma for potential reduction of vasogenic edema and steroid-sparing effects |clinical_trial_phase=Retrospective Studies |common_side_effects=Varies by specific ARB; can include dizziness, hypotension, and renal function alteration |OS_with=Not specified; studies have focused on steroid requirements...")
• 05:23, 24 March 2024 Lazy talk contribs created page Gleevec (Imatinib) (Created page with "{{TreatmentInfo |drug_name=Gleevec (Imatinib) |FDA_approval=Yes (for chronic myelogenous leukemia and other cancers, not specifically approved for gliomas) |used_for=Investigational use in gliomas, specifically targeting overexpression of platelet-derived growth factor receptor (PDGFR) |clinical_trial_phase=Exploratory/Investigational (Specific phase for gliomas not provided) |common_side_effects=Varies; for leukemia treatment includes fluid retention, nausea, muscle cra...")
• 05:14, 24 March 2024 Lazy talk contribs created page Category:Other Chemotherapy and Cancer Drugs (Created page with "Category:Other Chemotherapy and Cancer DrugsThis category encompasses a range of chemotherapy and cancer drugs used in the treatment of glioblastoma and other high-grade gliomas. These treatments are integral to multimodal cancer therapy approaches, combining traditional chemotherapy agents with newer, targeted drugs to improve patient outcomes.List of TreatmentsHere we provide an overview of various chemotherapy and cancer drugs categorized under "Other Chemotherapy and...")
• 05:12, 24 March 2024 Lazy talk contribs created page Bevacizumab (Avastin) (Created page with "{{TreatmentInfo |drug_name=Bevacizumab (Avastin) |FDA_approval=Yes, for recurrent glioblastoma |used_for=Glioblastoma |clinical_trial_phase=Phase III |common_side_effects=Hypertension, proteinuria, and hemorrhage |OS_with=AVAglio trial: 16.8 months; RTOG trial: 15.7 months |usefulness_rating=4 |notes=Avastin improves PFS when used initially, but no significant benefit for overall survival compared to Avastin given at recurrence. |category=Other Chemotherapy and Cancer Dr...")
• 05:11, 24 March 2024 Lazy talk contribs created page Procarbazine (Created page with "{{TreatmentInfo |drug_name=Procarbazine |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Not specified |common_side_effects=Hematological toxicity, nausea, and neurological effects |OS_with=Not specified |usefulness_rating=3 |notes=Combination of Temodar and procarbazine showed a high percentage of tumor regressions, suggesting effectiveness. |category=Other Chemotherapy and Cancer Drugs")
• 05:10, 24 March 2024 Lazy talk contribs created page Platinum Compounds (Created page with "{{TreatmentInfo |drug_name=Platinum Compounds (Cisplatin) |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Various, including Phase II |common_side_effects=Nephrotoxicity, ototoxicity, and neurotoxicity |OS_with=Not specified |usefulness_rating=3 |notes=Combining Temodar with cisplatin has shown improved PFS-6 in recurrent tumors. A protocol combining Temodar, cisplatin, and etoposide reported median survival of 25 months. |category=Other Chemotherapy and C...")
• 05:10, 24 March 2024 Lazy talk contribs created page BCNU (Carmustine) and Gliadel (Carmustine Wafers) (Created page with "{{TreatmentInfo |drug_name=BCNU and Gliadel Wafers |FDA_approval=Yes |used_for=High-grade gliomas |clinical_trial_phase=Phase III (Europe for Gliadel) |common_side_effects=Low blood counts, pulmonary problems, infection, and seizures for Gliadel |OS_with=Gliadel: 13.9 months median survival; Combination with TMZ: Median survival ranges from 17 to 20.7 months |usefulness_rating=4 |notes=While Gliadel wafers alone offer modest improvement, combining them with the standard...")
• 05:09, 24 March 2024 Lazy talk contribs created page CCNU (Lomustine) (Created page with "{{TreatmentInfo |drug_name=CCNU (Lomustine) |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Phase 3 (Germany) |common_side_effects=Hematological toxicity, nausea, vomiting, and pulmonary toxicity |OS_with=23 months median survival, with 47% at 2 years |usefulness_rating=4 |notes=A combination of TMZ with CCNU showed promising results including a 5-year survival rate of 16% among a small patient cohort. MGMT methylation status significantly influenced outco...")
• 04:55, 24 March 2024 Lazy talk contribs created page Category:Antibody-Drug Conjugates and other protein-drug conjugates (Created page with "== Introduction == Antibody-Drug Conjugates (ADCs) and other protein-drug conjugates represent a novel class of therapeutic agents in cancer treatment. These sophisticated therapies combine the specificity of antibodies or other proteins, which target specific markers on cancer cells, with potent cytotoxic drugs. This selective approach aims to minimize damage to healthy tissues while delivering powerful cancer-fighting agents directly to tumor cells. ADCs and similar c...")
• 04:53, 24 March 2024 Lazy talk contribs created page MDNA55 (Created page with "{{TreatmentInfo |drug_name=MDNA55 |FDA_approval=No |used_for=Recurrent malignant gliomas |clinical_trial_phase=Early phase trials |common_side_effects=Not specified in the provided text |OS_with=Not specified in the provided text |PFS_with=Not specified in the provided text |usefulness_rating=3 |notes=MDNA55, a fusion of IL-4 and Pseudomonas exotoxin A, targets cells with high IL-4R expression, common in tumor tissue. Preliminary data shows significant efficacy with a 56...")
• 04:52, 24 March 2024 Lazy talk contribs created page ABT-414 (Created page with "{{TreatmentInfo |drug_name=ABT-414 |FDA_approval=No |used_for=Targeting EGFR overexpressing glioblastoma cells |clinical_trial_phase=Phase 1 |common_side_effects=Eye toxicities, especially blurred vision |OS_with=Not reached at a median follow-up of 5.8 months |PFS_with=6.1 months for all patients, 5.9 months for EGFR amplified patients |usefulness_rating=2 |notes=ABT-414, an antibody-drug conjugate, selectively targets EGFR expressing tumor cells with minimal effects on...")
• 13:37, 23 March 2024 Lazy talk contribs created page Celebrex (Created page with "{{TreatmentInfo |drug_name=Celebrex (Celecoxib) and Other NSAIDs |FDA_approval=Yes (Celebrex is FDA-approved for arthritis and pain, but not specifically for cancer treatment) |used_for=Investigational use in cancer treatment due to anti-inflammatory, anti-angiogenic, and potential tumor growth inhibition properties |clinical_trial_phase=Early clinical trials and observational studies, including phase 2 trials combining Celebrex with conventional cancer treatments |commo...")
• 13:33, 23 March 2024 Lazy talk contribs created page Thyroid Hormone T4 (Thyroxine) Suppression (Created page with "{{TreatmentInfo |drug_name=Thyroid Hormone T4 Suppression Therapy |FDA_approval=No (Used off-label for cancer treatment; specific regimen for cancer not FDA-approved) |used_for=Investigational use in cancer treatment, particularly in glioblastoma, based on observations of improved outcomes with hypothyroid status |clinical_trial_phase=Early clinical trials and case studies, including a phase 2 clinical trial in Israel (NCT02654041) |common_side_effects=Carefully monitore...")
• 04:43, 21 March 2024 Lazy talk contribs created page Garlic (Created page with "{{TreatmentInfo |drug_name=Garlic (Allium sativum) |FDA_approval=No (Utilized as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in oncology, focusing on its cytotoxic effects against cancer cells and HDAC inhibition |clinical_trial_phase=Mostly preclinical, involving cell culture studies and some early-stage human research |common_side_effects=Generally well-tolerated; known side effects include gastrointestinal discomfort and...")
• 04:38, 21 March 2024 Lazy talk contribs created page Fish oil (Created page with "{{TreatmentInfo |drug_name=Fish Oil (Omega-3 Fatty Acids: EPA and DHA) |FDA_approval=No (Used as a dietary supplement; not specifically FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment for potential cytotoxic effects and enhancement of chemotherapy and radiation therapy efficacy |clinical_trial_phase=Clinical trials (e.g., advanced cancer study with cachexia, metastatic breast cancer Phase II trial, advanced non-small cell lung cancer...")
• 04:36, 21 March 2024 Lazy talk contribs created page Ellagic acid (Created page with "{{TreatmentInfo |drug_name=Ellagic Acid |FDA_approval=No (Utilized as a dietary component; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer prevention and treatment; noted for potential anti-cancer properties in laboratory studies |clinical_trial_phase=Preclinical and early clinical trials (e.g., prostate cancer study at UCLA) |common_side_effects=Not specifically documented; as a naturally occurring compound in fruits and nuts, it is genera...")
• 04:34, 21 March 2024 Lazy talk contribs created page Curcumin (Created page with "{{TreatmentInfo |drug_name=Curcumin |FDA_approval=No (Used as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment and prevention; also used for symptom management like dermatitis from radiotherapy |clinical_trial_phase=Preclinical studies and early clinical trials |common_side_effects=Generally well-tolerated; bioavailability issues are noted, but can be improved with piperine |OS_with=Not applicable; studies foc...")
• 04:18, 21 March 2024 Lazy talk contribs created page Cannabis (Created page with "{{TreatmentInfo |drug_name=Cannabis and Cannabis-derived Products (e.g., Sativex) |FDA_approval=Sativex is approved in Canada and some European countries for neuropathic pain; cannabis itself is not FDA-approved for cancer treatment |used_for=Investigational use in cancer treatment, including glioblastoma, for its direct anti-cancer and anti-nausea effects |clinical_trial_phase=Preclinical studies and early clinical trials, including a notable trial with Sativex for glio...")
• 04:15, 21 March 2024 Lazy talk contribs created page CBG (Created page with "{{TreatmentInfo |drug_name=Cannabigerol (CBG) |FDA_approval=No (CBG is a cannabinoid compound under investigation; not FDA-approved for any condition) |used_for=Investigational use in cancer research for potential anti-tumor effects |clinical_trial_phase=Preclinical studies and early research |common_side_effects=Not specifically documented; cannabinoids are generally considered to have a favorable safety profile, but specific studies on CBG's side effects are limited |O...")
• 04:14, 21 March 2024 Lazy talk contribs created page Sativex (Created page with "{{TreatmentInfo |drug_name=Sativex (Nabiximols) |FDA_approval=Not FDA-approved in the United States; approved in several countries for spasticity due to multiple sclerosis |used_for=Investigational use in glioblastoma for potential direct anti-tumor effects and symptom management |clinical_trial_phase=Phase 2 clinical trial in 2021 indicated for glioblastoma |common_side_effects=Fatigue, dizziness, nausea, mouth irritation |OS_with=The 2021 trial reported an increase in...")
• 04:13, 21 March 2024 Lazy talk contribs created page CBD (Created page with "{{TreatmentInfo |drug_name=CBD (Cannabidiol) |FDA_approval=Yes, for specific epilepsy syndromes; not FDA-approved for cancer treatment |used_for=Investigational use in cancer treatment, including symptom management and potential anti-tumor effects |clinical_trial_phase=Preclinical studies and early human trials for cancer |common_side_effects=Tiredness, diarrhea, changes in appetite/weight; generally well-tolerated at doses used for epilepsy |OS_with=Not applicable; ongo...")
• 04:05, 21 March 2024 Lazy talk contribs created page Metabolic therapy with Sodium R lipoate plus hydroxycitrate (Created page with "{{TreatmentInfo |drug_name=Sodium R Lipoate and Hydroxycitrate (METABLOC) |FDA_approval=No (Used in investigational metabolic therapy for brain tumors) |used_for=Investigational use in brain tumor treatment, including primary and metastatic gliomas |clinical_trial_phase=Early clinical evaluation in a small case series |common_side_effects=Not specified in the provided information |OS_with=Varies; one GBM patient had a significant tumor shrinkage, others showed extended p...")
• 04:03, 21 March 2024 Lazy talk contribs created page Limonene (Created page with "{{TreatmentInfo |drug_name=Perillyl Alcohol/Limonene |FDA_approval=No (Under investigation for anti-cancer properties) |used_for=Investigational use in recurrent glioma treatment |clinical_trial_phase=Early-stage clinical trials, including studies in Brazil for recurrent glioma |common_side_effects=Gastro-intestinal side effects when administered orally; intranasal administration used to mitigate this |OS_with=Primary GBM: median survival of 5.9 months; Secondary GBM: me...")
• 04:01, 21 March 2024 Lazy talk contribs created page GLA (Created page with "{{TreatmentInfo |drug_name=Gamma-Linolenic Acid (GLA) |FDA_approval=No (Used as a dietary supplement) |used_for=Considered for cancer treatment support, but recommended to use omega-3 fatty acids from fish oil instead |clinical_trial_phase=Preclinical (rodent studies) |common_side_effects=Not specifically mentioned; dietary supplements like GLA are generally well-tolerated |OS_with=Not applicable; current recommendations favor omega-3 fatty acids for potential CNS benefi...")
• 04:00, 21 March 2024 Lazy talk contribs created page PSK (Created page with "{{TreatmentInfo |drug_name=PSK (Polysaccharide Krestin) and other polysaccharides |FDA_approval=No (Widely used in Japan as a standard cancer treatment component) |used_for=Over-the-Counter supplement for immune system enhancement and potential cancer treatment adjunct |clinical_trial_phase=Various, mainly in Japan for cancers like stomach, colon, and non-small cell lung cancer |common_side_effects=Not extensively documented; generally considered safe with potential for...")
• 05:04, 20 March 2024 Lazy talk contribs created page Trial of three drugs plus temodar (Created page with "{{TreatmentInfo |drug_name=Combination of Repurposed Drugs plus Temodar |FDA_approval=Varies (individual drugs have separate FDA approvals for other conditions) |used_for=Investigational use in glioblastoma |clinical_trial_phase=Phase 1 and Phase 2 trials |common_side_effects=Varies based on the combination; potential for increased chemotherapy toxicity |OS_without=Standard treatment: median survival of 16.1 months |OS_with=Varies; one combination showed median survival...")
• 05:01, 20 March 2024 Lazy talk contribs created page Valproic acid (Created page with "{{TreatmentInfo |drug_name=Valproic Acid/Sodium Valproate (Depakote) |FDA_approval=Yes (for epilepsy) |used_for=Investigational use in glioblastoma for its HDAC inhibition properties |clinical_trial_phase=Retrospective studies and a prospective phase II trial |common_side_effects=Liver enzyme non-induction, potential increase in chemotherapy concentration, somnolence, constipation, potential liver toxicity |OS_without=Median survival with enzyme-inducing anticonvulsants:...")
• 02:26, 20 March 2024 Lazy talk contribs created page Valcyte (Created page with "{{TreatmentInfo |drug_name=Valganciclovir (Valcyte) |FDA_approval=Yes (for CMV infections) |used_for=Investigational use in glioblastoma due to potential effects against CMV positive tumors |clinical_trial_phase=Investigational, including early clinical trials |common_side_effects=Includes diarrhea, nausea, neutropenia, potential for increased risk of birth defects |OS_without=Median survival with standard treatment: 17.4 months |OS_with=Post-hoc analysis with at least s...")
• 02:18, 20 March 2024 Lazy talk contribs created page Thalidomide (Created page with "{{TreatmentInfo |drug_name=Thalidomide |FDA_approval=Yes (for leprosy and multiple myeloma) |used_for=Investigational use in various cancers due to antiangiogenic and immunomodulatory properties |clinical_trial_phase=Ongoing optimization of thalidomide analogues |common_side_effects=Deep vein thrombosis, peripheral neuropathy, constipation, somnolence, pyrexia, pain, teratogenicity |OS_with=Not specified; ongoing studies for cancer-specific outcomes |PFS_with=Not specifi...")