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Property Information
Drug Name Garlic (Allium sativum)
FDA Approval No (Utilized as a dietary supplement; not FDA-approved for cancer treatment)
Used for Investigational use in oncology, focusing on its cytotoxic effects against cancer cells and HDAC inhibition
Clinical Trial Phase Mostly preclinical, involving cell culture studies and some early-stage human research
Clinical Trial Explanation Not specified
Common Side Effects Generally well-tolerated; known side effects include gastrointestinal discomfort and a strong odor. Rare cases of allergic reactions.
OS without Not specified
OS with Not applicable; the majority of evidence is from preclinical studies, without detailed human data on overall survival impacts.
PFS without Not specified
PFS with Not applicable; current research has not progressed to detailed assessments of progression-free survival in cancer patients.
Usefulness Rating 3
Usefulness Explanation Not specified
Toxicity Level 1
Toxicity Explanation Garlic is used as a dietary supplement and is generally well-tolerated by most people. The most common side effects reported include gastrointestinal discomfort and a strong odor. There is currently not enough research to suggest that garlic as a treatment for glioblastoma has severe toxic side effects. So, it has a low toxicity level of 1.

Notes: Garlic, recognized for centuries for its medicinal properties, has shown promise in preclinical studies for its potential anti-cancer effects. These include inducing apoptosis in glioblastoma cell lines and acting as a potent HDAC inhibitor. While these mechanisms suggest garlic could play a role in cancer prevention and possibly treatment, comprehensive clinical trials are needed to substantiate its efficacy and determine its therapeutic utility in oncology.

From Ben Williams Book: Not specified

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