Letrozole
| Property | Information |
|---|---|
| Drug Name | Letrozole |
| FDA Approval | Yes (approved for breast cancer; not specifically approved for brain cancer yet) |
| Used for | Experimental for glioblastoma; approved for hormone receptor-positive breast cancer |
| Clinical Trial Phase | Phase 2 |
| Clinical Trial Explanation | Not specified |
| Common Side Effects | Hot flashes, joint pain, nausea, increased risk of osteoporosis, fatigue |
| OS without | Not specified |
| OS with | Not specified |
| PFS without | Not specified |
| PFS with | Not specified |
| Usefulness Rating | 3 - Under investigation |
| Usefulness Explanation | Not specified |
| Toxicity Level | 2.5 |
| Toxicity Explanation | The treatment's toxicity level is rated at 2.5 out of a possible 5. This suggests that the treatment has some side effects, which can include hot flashes, joint pain, nausea, an increased risk of osteoporosis, and fatigue. However, these side effects are typically manageable and are considered moderate in comparison to other treatments. It's important to note that these side effects may not be experienced by everyone and can vary in intensity from person to person. Also, this drug is still in the experimental phase for glioblastoma and is not yet specifically approved for this type of brain cancer. The exact toxicity could change as more research is done. |
Notes: A collaborative study by the University of Cincinnati Cancer Center has initiated a Phase 2 trial to investigate the effectiveness of Letrozole in treating glioblastoma. This follows observations that certain breast cancer drugs, like Letrozole, which is used to treat hormone receptor-positive breast cancer, could be repurposed to inhibit the growth of glioblastoma cells by targeting estrogen receptors. The study is focused on understanding how Letrozole, when combined with standard therapy, affects the progression and treatment outcomes in glioblastoma patients.
Links: [University of Cincinnati article on Phase 2 brain tumor trial with Letrozole](https://www.uc.edu/news/articles/2024/02/collaborative-uc-cancer-center-team-opens-phase-2-brain-tumor-trial.html), [Brain Tomorrow's discussion on breast cancer drug Letrozole for glioblastoma](https://braintomorrow.com/breast-cancer-drug-letrozole-glioblastoma/)
From Ben Williams Book: Not specified
