Gamma Knife Radiosurgery
| Property | Information |
|---|---|
| Drug Name | Gamma Knife Radiosurgery (GKRS) for GBM |
| Overview | Gamma Knife Radiosurgery (GKRS) offers a promising and safer alternative for treating newly diagnosed Glioblastoma Multiforme (GBM), characterized by lower toxicity and comparable overall and progression-free survival rates compared to standard treatments. This established modality, particularly when using fractionated sessions with the Gamma Knife ICON, emphasizes patient safety while highlighting the need for further research to optimize treatment protocols. |
| FDA Approval | Yes |
| Used for | Newly diagnosed Glioblastoma Multiforme (GBM) |
| Clinical Trial Phase | N/A (Established treatment modality) |
| Clinical Trial Explanation | Not specified |
| Common Side Effects | Lower compared to traditional GBM treatments, with no significant radiation-induced toxicities reported in recent studies. |
| OS without | 14-16 months with standard treatment. |
| OS with | Comparable to standard treatment, specifics depend on individual patient factors. |
| PFS without | Typically, tumors recur within 6 months of standard treatment. |
| PFS with | 5.6 months reported in recent studies using fractionated sessions with Gamma Knife ICON. |
| Usefulness Rating | 3 |
| Usefulness Explanation | The primary advantage of GKRS for GBM lies in its lower toxicity profile, offering a safer treatment option for select patients without compromising on the progression-free survival (PFS) or overall survival (OS) rates. |
| Toxicity Level | 2 |
| Toxicity Explanation | GKRS, especially when utilized in a fractionated approach with the Gamma Knife ICON, presents a viable treatment option for GBM patients, emphasizing reduced side effects while maintaining efficacy. |
Links: https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10162-w
From Ben Williams Book: Gamma Knife Radiosurgery (GKRS) provides a novel approach for the management of newly diagnosed glioblastoma (GBM), emphasizing lower toxicity without significant alteration in progression-free or overall survival rates. This treatment modality, particularly with the advent of fractionated sessions using the Gamma Knife ICON, indicates a strategic shift towards maximizing patient safety and treatment tolerability. Further investigation in a prospective setting is warranted to fully ascertain the benefits and optimize treatment protocols.Property "Has original text" (as page type) with input value "Gamma Knife Radiosurgery (GKRS) provides a novel approach for the management of newly diagnosed glioblastoma (GBM), emphasizing lower toxicity without significant alteration in progression-free or overall survival rates. This treatment modality, particularly with the advent of fractionated sessions using the Gamma Knife ICON, indicates a strategic shift towards maximizing patient safety and treatment tolerability. Further investigation in a prospective setting is warranted to fully ascertain the benefits and optimize treatment protocols." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
