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16:20, 11 November 2024 Lazy talk contribs created page Template:GroupingFragmentJSON (Created page with "{ "grouping": "{{{grouping|}}}", "categories": [ {{#arraymap: {{#ask: [[Belongs to Grouping::{{{grouping}}}]]|?Category|format=list|sep=,}} |,|@| { "category": "@", "treatments": [ {{#arraymap: {{#ask: Belongs to Category::@|?Has treatment name|?Has Usefulness Rating|?Has Toxicity Level|format=list|sep=,}} |,|@@| { "name": "@@", "usefulness_rating": "{{...")
13:23, 11 November 2024 Lazy talk contribs created page Template:TreatmentJSON (Created page with "{ "name": "{{{Has treatment name|}}}", "usefulness_rating": "{{{Has Usefulness Rating|}}}", "toxicity_level": "{{{Has Toxicity Level|}}}" }")
13:23, 11 November 2024 Lazy talk contribs created page Template:CategoryJSON (Created page with "{ "category": "{{{category|}}}", "treatments": [ {{#ask: [[Belongs to Category::{{{category|}}}]] |?Has treatment name |?Has Usefulness Rating |?Has Toxicity Level |format=template |template=TreatmentJSON |sep=, }} ] }")
13:22, 11 November 2024 Lazy talk contribs created page Template:GroupingJSON (Created page with "{ "grouping": "{{{grouping|}}}", "categories": [ {{#ask: [[Belongs to Grouping::{{{grouping|}}}]] |?Category |format=template |template=CategoryJSON |sep=, }} ] }")
13:18, 11 November 2024 Lazy talk contribs created page Research It Yourself JSON (Created page with "{{#ask: Has Access::Research It Yourself | ?Belongs to Grouping | ?Category | ?Has treatment name | ?Has Usefulness Rating | ?Has Toxicity Level | format=json | mainlabel=- | headers=hide | link=none }}")
12:26, 11 November 2024 Lazy talk contribs created page Over-the-Counter Drugs and Supplements (Created page with "=== Over-the-Counter Drugs and Supplements === There are a number of agents available over-the-counter that have promising anti-cancer properties, and it is reasonable to believe that these can increase the chances of surviving. Some of these with supporting clinical evidence (e.g., proton pump inhibitors such as Prilosec) have been discussed above. A frequent conflict between patients and their oncologists is that patients, often desperate to find treatment agents that...")
12:16, 11 November 2024 Lazy talk contribs created page Nutraceuticals and Herbals (Created page with "==== Nutraceuticals and Herbals ==== Oncologists routinely warn their patients not to use supplements, usually based on the belief that supplements that are anti-oxidants will interfere with both radiation and chemotherapy. While this issue is extremely complex, my own evaluation of the relevant evidence strongly disagrees with this opinion. Accordingly, I have posted my own analysis of the clinical evidence as an accompanying article on this website. Here I list the sup...")
09:53, 11 November 2024 Lazy talk contribs created page Complementary and Self-Directed Therapies (Created page with "== Complementary and Self-Directed Therapies == This grouping includes therapies that patients may pursue on their own or in combination with conventional treatments. Such therapies often focus on holistic wellness, lifestyle adjustments, and alternative health practices that aim to support overall health and well-being. Examples include herbal supplements, mindfulness practices, acupuncture, and dietary interventions. These approaches typically require a self-directed...")
09:37, 11 November 2024 Lazy talk contribs created page Alternative Treatment Centers and Clinics (Created page with "== Alternative Treatment Centers and Clinics == This grouping includes centers and clinics that offer alternative or integrative treatments not commonly found in standard medical settings. These facilities may specialize in complementary therapies, holistic care, or experimental approaches designed to support traditional cancer treatments or provide alternative options for patients seeking more personalized care. Has Access::Research It Yourself Category:Grouping")
09:37, 11 November 2024 Lazy talk contribs created page Specialized Treatments (Created page with "== Specialized Treatments == Specialized treatments refer to unique or advanced therapeutic approaches that are typically offered in select treatment centers or clinics. These treatments may include novel therapies, personalized medicine options, or other specialized interventions designed to meet the needs of patients with specific medical conditions. Belongs to Grouping::Alternative Treatment Centers and Clinics Category:Category")
07:49, 11 November 2024 Lazy talk contribs created page Template:AccessGroupings (Created page with "== Groupings in this Access Level == {{#ask: [[Has Access::{{{1|}}}]] | mainlabel=Grouping | headers=plain | format=table }}")
07:40, 11 November 2024 Lazy talk contribs created page Template:GroupingCategories (Created page with "== Categories in this Grouping == {{#ask: [[Belongs to Grouping::{{{1|}}}]] | ?Category=Category | mainlabel=Category | headers=plain | format=table }}")
07:38, 11 November 2024 Lazy talk contribs created page Integrative Oncologist (Created page with "== Integrative Oncologist == Integrative oncologists combine conventional oncology treatments with complementary therapies aimed at enhancing overall wellness and supporting the body’s natural defenses. These practitioners may incorporate dietary guidance, lifestyle changes, mind-body practices, and evidence-based nutraceuticals into a holistic cancer care plan. This approach is typically pursued by patients who are interested in supplementing standard cancer treatme...")
07:25, 11 November 2024 Lazy talk contribs created page Standard Treatments (Created page with "== Standard Treatments == This grouping includes well-established treatment modalities that are part of conventional oncology care. Has Access::Standard Oncology Category:Grouping")
07:19, 11 November 2024 Lazy talk contribs created page Research It Yourself (Created page with "== Research It Yourself == This access level includes innovative or emerging therapies that are less commonly available through conventional oncology. Patients may need to do independent research or pursue these options outside standard medical frameworks.")
07:19, 11 November 2024 Lazy talk contribs created page Standard Oncology (Created page with "== Standard Oncology == This access level includes treatments and approaches that are well-established within conventional oncology. These treatments are commonly offered in medical settings and have extensive clinical support.")
21:12, 29 September 2024 Lazy talk contribs created page File:Metformin.png
21:12, 29 September 2024 Lazy talk contribs uploaded File:Metformin.png
19:44, 13 June 2024 Lazy talk contribs created page Anlotinib (Created page with "{{TreatmentInfo |drug_name=Anlotinib |FDA_approval=Under investigation; not yet FDA-approved |used_for=Various cancers including Non-Small Cell Lung Cancer (NSCLC), Soft Tissue Sarcoma, and Renal Cell Carcinoma; being investigated for Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase 2 and 3 (for different cancers); early-stage trials for GBM |common_side_effects=Hypertension, fatigue, hand-foot syndrome, diarrhea, proteinuria, thyroid dysfunction |OS_without=Med...")
20:02, 29 May 2024 Lazy talk contribs created page Plotly (Created page with "== Glioblastoma Treatments == <div id="categories"></div> <div id="plot"></div>  <script src="https://cdn.plot.ly/plotly-latest.min.js"></script>  <script src="/index.php?title=MediaWiki:InteractivePlot.js&action=raw&ctype=text/javascript"></script>")
20:00, 29 May 2024 Lazy talk contribs created page MediaWiki:InteractivePlot.js (Created page with "$(document).ready(function() { // Fetch the JSON data from the query result page fetch('https://glioblastomatreatments.wiki/index.php?title=Special:Ask/-5B-5BHas-20Usefulness-20Rating::%2B-5D-5D/-3FHas-20treatment-20name%3DTreatment-20Name/-3FHas-20Usefulness-20Rating%3DUsefulness-20Rating/-3FHas-20Toxicity-20Level%3DToxicity-20Level/-3FCategory/mainlabel%3D-2D/limit%3D100/offset%3D0/format%3Djson') .then(response => response.json()) .then(data => {...")
19:55, 29 May 2024 Lazy talk contribs created page Plot (Created page with "<div id="categories"></div> <div id="plot"></div> <script src="https://cdn.plot.ly/plotly-latest.min.js"></script> <script> // Fetch the JSON data from the query result page fetch('https://glioblastomatreatments.wiki/index.php?title=Special:Ask/-5B-5BHas-20Usefulness-20Rating::%2B-5D-5D/-3FHas-20treatment-20name%3DTreatment-20Name/-3FHas-20Usefulness-20Rating%3DUsefulness-20Rating/-3FHas-20Toxicity-20Level%3DToxicity-20Level/-3FCategory/mainlabel%3D-2D/limit%3D1...")
16:00, 29 May 2024 Lazy talk contribs created page Treatments Plot (Created page with "== Glioblastoma Treatments == <div id="categories"></div> <div id="plot"></div> <script src="https://cdn.plot.ly/plotly-latest.min.js"></script> <script> // Fetch the JSON data from the query result fetch('/index.php?title=Special:Ask&format=json&q=Category:Treatments|%3FHas+treatment+name=Treatment|%3FHas+Effectiveness=Effectiveness|%3FHas+Toxicity=Toxicity|%3FHas+Category=Category|format=json|link=none|headers=hide|mainlabel=-') .then(response => resp...")
19:12, 17 May 2024 Lazy talk contribs created page Metronomic low dose temozolomide (TMZ) (Created page with "{{TreatmentInfo |drug_name=Metronomic Low-Dose Temozolomide (TMZ) |FDA_approval=FDA-approved for glioblastoma but standard metronomic dosing is still under investigation |used_for=Glioblastoma Multiforme (GBM), recurrent GBM |clinical_trial_phase=Phase II and III for metronomic dosing schedules |common_side_effects=Nausea, vomiting, fatigue, myelosuppression, lymphopenia |OS_without=Median overall survival for GBM is typically 15-17 months from diagnosis |OS_with=Studies...")
09:03, 17 May 2024 Lazy talk contribs created page Hyperthermia (Created page with "{{TreatmentInfo |drug_name=Hyperthermia |FDA_approval=Investigational |used_for=Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase I/II |common_side_effects=Localized discomfort, potential damage to surrounding healthy tissue |OS_without=Standard progression statistics for GBM |OS_with=Extended survival reported in some clinical trials |PFS_without=Standard progression statistics for GBM |PFS_with=Improved progression-free survival in combination with other treatm...")
15:01, 15 May 2024 Lazy talk contribs created page Chronotherapy (Created page with "{{TreatmentInfo |drug_name=Chronotherapy with Temozolomide (TMZ) |FDA_approval=Yes (as part of standard glioblastoma treatment) |used_for=Glioblastoma Multiforme (GBM) |clinical_trial_phase=Research ongoing |common_side_effects=Increased side effects when administered in the morning; however, these are generally manageable with other therapies. |OS_without=Around 19.5 months for patients with MGMT methylated tumors. |OS_with=Up to 17 months for general cases, and up to 2...")
09:57, 28 April 2024 Lazy talk contribs created page Parthenolide (Created page with "{{TreatmentInfo |drug_name=Parthenolide |FDA_approval=No (Used primarily in research settings; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment, specifically for its effects on glioblastoma and glioma stem cells |clinical_trial_phase=Preclinical studies |clinical_trial_explanation=Parthenolide is being studied for its potential anti-cancer properties in glioblastoma, particularly focusing on its ability to target and kill glioma st...")
09:53, 28 April 2024 Lazy talk contribs created page Metformin (Created page with "{{TreatmentInfo |drug_name=Metformin |FDA_approval=Yes (Approved for type 2 diabetes; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment, specifically studied for effects on glioblastoma and glioma stem cells |clinical_trial_phase=Preclinical studies and some clinical trials |clinical_trial_explanation=Metformin is under investigation for its potential anti-cancer properties in glioblastoma, particularly its effects on glioma stem ce...")
09:47, 28 April 2024 Lazy talk contribs created page Sulforaphane (Created page with "{{TreatmentInfo |drug_name=Sulforaphane |FDA_approval=No (Used as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment, particularly in preclinical studies focusing on glioblastoma |clinical_trial_phase=Preclinical studies |clinical_trial_explanation=Sulforaphane is being studied in preclinical models for its potential as an anti-cancer agent against glioblastoma. Research focuses on its ability to inhibit histone...")
09:46, 28 April 2024 Lazy talk contribs created page Resveratrol (Created page with "{{TreatmentInfo |drug_name=Resveratrol |FDA_approval=No (Used as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment and prevention; also studied for cardiovascular benefits and anti-aging properties |clinical_trial_phase=Preclinical studies and early clinical trials |clinical_trial_explanation=Resveratrol is being studied for its potential anti-cancer properties in preclinical and early clinical trials, focusing...")
20:19, 5 April 2024 Lazy talk contribs created page Beta-blockers (especially propranolol) and the role of the sympathetic (Created page with " {{TreatmentInfo |drug_name=Beta-blockers (especially propranolol) and the role of the sympathetic |category=Hormones and Cancer Therapy |book_text=nervous system Recenty the role of the sympathetic nervous system in cancer progression, and the potential role of beta-adrenergic antagonists (beta-blockers) have come into focus in some corners of the cancer research community. Early studies linking stress to increased rates of cancer progression led to epidemiological st...")
20:19, 5 April 2024 Lazy talk contribs created page Angiotensin-Il Receptor Blockers (ARB) (Created page with " {{TreatmentInfo |drug_name=Angiotensin-Il Receptor Blockers (ARB) |category=Hormones and Cancer Therapy |book_text=Angiotensin-II is a peptide hormone produced from angiotensin-I by the action of angiotensin converting enzyme (ACE). The main effect of angiotensin-II is vasoconstriction and a resulting increase in blood pressure. Therefore ACE inhibitors and angiotensin-II receptor blockers are used as anti-hypertensive drugs, especially in heart disease. More recently...")
20:18, 5 April 2024 Lazy talk contribs created page Herpes Virus (Created page with " {{TreatmentInfo |drug_name=Herpes Virus |category=Oncolytic virotherapy |book_text=Another virus used in cancer therapy is a modified form of the herpes virus. Initial trials used a retrovirus version, which infects only those cells dividing when the virus was infused. Subsequent trials have used an adenovirus version, which infects both dividing and non-dividing cells. Because the herpes virus can be lethal to the brain if allowed to proliferate, soon after the virus...")
20:18, 5 April 2024 Lazy talk contribs created page Newcastle Disease Virus (Created page with " {{TreatmentInfo |drug_name=Newcastle Disease Virus |category=Oncolytic virotherapy |book_text=An alternative approach to vaccine treatment utilizes viruses. Newcastle disease is a lethal chicken disease, which is caused by a virus that is innocuous to humans, causing only transitory mild flu-like symptoms. It was developed as a cancer treatment in Hungary but has largely been ignored in this country until only recently. Newcastle Disease Virus is currently being utiliz...")
20:18, 5 April 2024 Lazy talk contribs created page DNX-2401 adenovirus (Created page with " {{TreatmentInfo |drug_name=DNX-2401 adenovirus |category=Oncolytic virotherapy |book_text=Another viral therapy in phase 1 has had impressive results, comparable to the PVS-RIPO trial. DNX-2401 is a modified adenovirus that is directly injected into the tumor. Preliminary results of a phase 1 trial at MD Anderson in Houston, Texas were presented at the November 2014 SNO conference in Miami. 37 recurrent high-grade glioma patients had been treated, with no adverse event...")
20:18, 5 April 2024 Lazy talk contribs created page Genetically modified Poliovirus (PVS-RIPO) (Created page with " {{TreatmentInfo |drug_name=Genetically modified Poliovirus (PVS-RIPO) |category=Oncolytic virotherapy |book_text=In 2015, this phase I trial for recurrent glioblastoma at Duke University received a boost in public interest when an episode of the television show 60 minutes was devoted to it. Most exceptionally, the first two patients treated in this study were complete responders. As of March 2015 (when the 60 minutes special aired) these two complete responders were st...")
13:27, 31 March 2024 Lazy talk contribs created page Wilms Tumor 1 (WT1) Peptide Vaccine (Created page with "{{TreatmentInfo |drug_name=Wilms Tumor 1 (WT1) Peptide Vaccine |FDA_approval=In clinical trials; not yet FDA-approved |used_for=Newly diagnosed and recurrent Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase II (Based on the latest clinical trial data available) |common_side_effects=Local erythema at the injection site; overall, the treatment is well-tolerated |OS_without=Typical median overall survival for GBM with standard treatment is about 15-17 months |OS_wi...")
13:23, 31 March 2024 Lazy talk contribs created page Rindopepimut (CDX-110) (Created page with "{{TreatmentInfo |drug_name=Rindopepimut (CDX-110) |FDA_approval=Not FDA-approved; received Breakthrough Therapy designation for glioblastoma in Feb 2015 |used_for=EGFRvIII-positive Glioblastoma Multiforme (GBM) in newly diagnosed and recurrent cases |clinical_trial_phase=Phase III for newly diagnosed GBM was discontinued; Phase II for recurrent GBM showed promising results |common_side_effects=Transient, low-grade local reactions; overall well-tolerated |OS_without=Media...")
13:19, 31 March 2024 Lazy talk contribs created page Anti-CMV Dendritic Cell Vaccine (Created page with "{{TreatmentInfo |drug_name=Anti-CMV Dendritic Cell Vaccine |FDA_approval=In clinical trials; not yet FDA-approved |used_for=Newly diagnosed and recurrent Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase II |common_side_effects=Not detailed; dendritic cell vaccines are generally well-tolerated with mild side effects. |OS_without=Historical controls indicate median overall survival around 15-17 months for newly diagnosed GBM. |OS_with=Varied; one study showed medi...")
13:14, 31 March 2024 Lazy talk contribs created page SL-701 (Created page with "{{TreatmentInfo |drug_name=SL-701 (Immunotherapy Vaccine) |FDA_approval=In clinical trials; not yet FDA-approved |used_for=Relapsed or refractory Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase II |common_side_effects=Fatigue, injection site reaction, erythema, and pain were the most common treatment-related adverse events. No grade 4/5 adverse events reported, indicating a manageable safety profile. |OS_without=Historical controls suggest a median overall surv...")
13:10, 31 March 2024 Lazy talk contribs created page ICT-107 (Created page with "{{TreatmentInfo |drug_name=ICT-107 (Tumor-associated Antigen Vaccine) |FDA_approval=Still in clinical trials; not yet FDA-approved |used_for=Newly diagnosed and recurrent Glioblastoma Multiforme (GBM) |clinical_trial_phase=Phase III |common_side_effects=Reported side effects are minimal, including potential site reactions and flu-like symptoms. Few serious adverse events related to the vaccine have been reported. |OS_without=Median overall survival for GBM typically rang...")
13:06, 31 March 2024 Lazy talk contribs created page Agenus Prophage (Heat-Shock Protein Peptide Complex-96) Vaccine (Created page with "{{TreatmentInfo |drug_name=Agenus Prophage (Heat-Shock Protein Peptide Complex-96) Vaccine |FDA_approval=In clinical trials; not yet FDA-approved |used_for=Recurrent heavily pretreated glioblastoma multiforme (GBM) and newly diagnosed GBM |clinical_trial_phase=Phase II |common_side_effects=Not explicitly detailed; similar immunotherapy treatments often include flu-like symptoms, injection site reactions, fatigue |OS_without=Historical controls suggest a median survival t...")
13:01, 31 March 2024 Lazy talk contribs created page Dendritic Cell Vaccine (DCVax-L) (Created page with "{{TreatmentInfo |drug_name=Dendritic Cell Vaccine (DCVax-L) |FDA_approval=Under investigation; not yet FDA-approved |used_for=Glioblastoma Multiforme (GBM), both newly diagnosed and recurrent |clinical_trial_phase=Phase 3 |common_side_effects=Intracranial edema, nausea, lymph node infection (rare and manageable) |OS_without=Median overall survival for GBM is typically 15-17 months from diagnosis, or 8 months from recurrence |OS_with=Median overall survival of 19.3 months...")
10:03, 31 March 2024 Lazy talk contribs created page Property:Has Toxicity Explanation (Created page with "Has type::Text")
20:49, 30 March 2024 Lazy talk contribs created page CPT-11 (Irinotecan) (Created page with "{{TreatmentInfo |drug_name=CPT-11 (Irinotecan) |FDA_approval=Approved for the treatment of colon cancer; under investigation for recurrent glioma |used_for=Recurrent Glioblastoma Multiforme (GBM) and other malignant gliomas |clinical_trial_phase=Phase I/II trials in combination with other therapies |common_side_effects=Hematologic, gastrointestinal, and hepatic toxicities noted; acceptable safety profile in combination regimens |OS_without=Not directly specified; histori...")
20:47, 30 March 2024 Lazy talk contribs created page Carboplatin (Created page with "{{TreatmentInfo |drug_name=Carboplatin |FDA_approval=Yes, approved for various cancers including ovarian and lung cancer; used off-label for GBM |used_for=Recurrent Glioblastoma Multiforme (GBM) and high-grade glioma |clinical_trial_phase=Exploratory and Phase 1/2 trials for recurrent glioma in combination with other agents |common_side_effects=Less toxicity compared to cisplatin, but may include myelosuppression, nausea, and potential for liver enzyme elevation |OS_with...")
20:45, 30 March 2024 Lazy talk contribs created page Fotemustine (Created page with "{{TreatmentInfo |drug_name=Fotemustine |FDA_approval=Available in Europe, not FDA-approved in the United States for GBM |used_for=Recurrent Glioblastoma Multiforme (GBM) after the standard Stupp protocol treatment |clinical_trial_phase=Varied, with multiple studies evaluating efficacy and optimal scheduling |common_side_effects=Not specified, typical of nitrosoureas may include myelosuppression, nausea, and liver enzyme elevation |OS_without=Not specified |OS_with=Not sp...")
20:42, 30 March 2024 Lazy talk contribs created page BCNU (Carmustine) (Created page with "{{TreatmentInfo |drug_name=BCNU (Carmustine) |FDA_approval=Yes, approved for treatment of brain tumors, multiple myeloma, Hodgkin's disease, and non-Hodgkin's lymphomas |used_for=Recurrent Glioblastoma Multiforme (GBM) after radiation treatment |clinical_trial_phase=Various, given its long history of use |common_side_effects=Hepatic and pulmonary toxicity, myelosuppression |OS_without=Not specified in the provided context |OS_with=Not specified in the provided context |P...")
20:39, 30 March 2024 Lazy talk contribs created page VAL-083 (Dianhydrogalactitol) (Created page with "{{TreatmentInfo |drug_name=VAL-083 (Dianhydrogalactitol) |FDA_approval=Approved in China for CML and lung cancer; not yet approved outside of China for GBM |used_for=Recurrent Glioblastoma Multiforme (GBM) with unmethylated MGMT promoter |clinical_trial_phase=Phase 2 (ongoing evaluation in GBM AGILE for various GBM subtypes) |common_side_effects=Myelosuppression, including neutropenia and lymphopenia; some instances of serious adverse events possibly related to VAL-083 |...")
09:20, 30 March 2024 Lazy talk contribs created page Template:CustomTextDisplay (Created page with "{{{Has original text|}}}")

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