Hyperthermia

Property	Information
Drug Name	Hyperthermia
FDA Approval	Investigational
Used for	Glioblastoma Multiforme (GBM)
Clinical Trial Phase	Phase I/II
Clinical Trial Explanation	Several clinical trials have investigated the benefits of hyperthermia for glioblastoma. A prospective randomized trial at UCSF combined hyperthermia with brachytherapy, showing a significant survival benefit. Other studies are exploring hyperthermia with gold nanoparticles for targeted heating, potentially increasing efficacy while minimizing damage to healthy tissues.Property "Has clinical trial explanation" (as page type) with input value "Several clinical trials have investigated the benefits of hyperthermia for glioblastoma. A prospective randomized trial at UCSF combined hyperthermia with brachytherapy, showing a significant survival benefit. Other studies are exploring hyperthermia with gold nanoparticles for targeted heating, potentially increasing efficacy while minimizing damage to healthy tissues." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Common Side Effects	Localized discomfort, potential damage to surrounding healthy tissue
OS without	Standard progression statistics for GBM
OS with	Extended survival reported in some clinical trials
PFS without	Standard progression statistics for GBM
PFS with	Improved progression-free survival in combination with other treatments
Usefulness Rating	4
Usefulness Explanation	Hyperthermia has shown potential in enhancing the effectiveness of radiation and chemotherapy, improving overall survival and progression-free survival rates in glioblastoma patients.
Toxicity Level	3
Toxicity Explanation	While hyperthermia can cause discomfort and risk damage to healthy tissues, these effects are generally manageable with precise control and monitoring.

Notes: Hyperthermia treatment involves raising the temperature of tumor tissues to enhance the effectiveness of conventional cancer therapies such as radiation and chemotherapy. This method leverages heat to induce cellular stress and damage in cancer cells, making them more susceptible to other treatments. For glioblastoma, an aggressive brain tumor, hyperthermia has shown potential in improving treatment outcomes and extending patient survival.

Links: https://consultqd.clevelandclinic.org/turning-up-the-heat-on-glioblastoma-with-thermal-medicine/, https://brio-medical.com/hyperthermia-activation-in-treating-glioblastoma/, https://cancer.ucsf.edu/research/clinical-trials

From Ben Williams Book: Not specified

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