Garlic

Property	Information
Drug Name	Garlic (Allium sativum)
FDA Approval	No (Utilized as a dietary supplement; not FDA-approved for cancer treatment)
Used for	Investigational use in oncology, focusing on its cytotoxic effects against cancer cells and HDAC inhibition
Clinical Trial Phase	Mostly preclinical, involving cell culture studies and some early-stage human research
Clinical Trial Explanation	Not specified
Common Side Effects	Generally well-tolerated; known side effects include gastrointestinal discomfort and a strong odor. Rare cases of allergic reactions.
OS without	Not specified
OS with	Not applicable; the majority of evidence is from preclinical studies, without detailed human data on overall survival impacts.
PFS without	Not specified
PFS with	Not applicable; current research has not progressed to detailed assessments of progression-free survival in cancer patients.
Usefulness Rating	3
Usefulness Explanation	Not specified
Toxicity Level	1
Toxicity Explanation	Garlic is used as a dietary supplement and is generally well-tolerated by most people. The most common side effects reported include gastrointestinal discomfort and a strong odor. There is currently not enough research to suggest that garlic as a treatment for glioblastoma has severe toxic side effects. So, it has a low toxicity level of 1.

Notes: Garlic, recognized for centuries for its medicinal properties, has shown promise in preclinical studies for its potential anti-cancer effects. These include inducing apoptosis in glioblastoma cell lines and acting as a potent HDAC inhibitor. While these mechanisms suggest garlic could play a role in cancer prevention and possibly treatment, comprehensive clinical trials are needed to substantiate its efficacy and determine its therapeutic utility in oncology.

From Ben Williams Book: Not specified

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