Garlic
From Glioblastoma Treatments
Property | Information |
---|---|
Drug Name | Garlic (Allium sativum) |
FDA Approval | No (Utilized as a dietary supplement; not FDA-approved for cancer treatment) |
Used for | Investigational use in oncology, focusing on its cytotoxic effects against cancer cells and HDAC inhibition |
Clinical Trial Phase | Mostly preclinical, involving cell culture studies and some early-stage human research |
Clinical Trial Explanation | Not specified |
Common Side Effects | Generally well-tolerated; known side effects include gastrointestinal discomfort and a strong odor. Rare cases of allergic reactions. |
OS without | Not specified |
OS with | Not applicable; the majority of evidence is from preclinical studies, without detailed human data on overall survival impacts. |
PFS without | Not specified |
PFS with | Not applicable; current research has not progressed to detailed assessments of progression-free survival in cancer patients. |
Usefulness Rating | 3 |
Usefulness Explanation | Not specified |
Toxicity Level | 1 |
Toxicity Explanation | Garlic is used as a dietary supplement and is generally well-tolerated by most people. The most common side effects reported include gastrointestinal discomfort and a strong odor. There is currently not enough research to suggest that garlic as a treatment for glioblastoma has severe toxic side effects. So, it has a low toxicity level of 1. |
Notes: Garlic, recognized for centuries for its medicinal properties, has shown promise in preclinical studies for its potential anti-cancer effects. These include inducing apoptosis in glioblastoma cell lines and acting as a potent HDAC inhibitor. While these mechanisms suggest garlic could play a role in cancer prevention and possibly treatment, comprehensive clinical trials are needed to substantiate its efficacy and determine its therapeutic utility in oncology.
From Ben Williams Book: Not specified
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