Hyperthermia
From Glioblastoma Treatments
| Property | Information |
|---|---|
| Drug Name | Hyperthermia |
| FDA Approval | Investigational |
| Used for | Glioblastoma Multiforme (GBM) |
| Clinical Trial Phase | Phase I/II |
| Clinical Trial Explanation | Several clinical trials have investigated the benefits of hyperthermia for glioblastoma. A prospective randomized trial at UCSF combined hyperthermia with brachytherapy, showing a significant survival benefit. Other studies are exploring hyperthermia with gold nanoparticles for targeted heating, potentially increasing efficacy while minimizing damage to healthy tissues.Property "Has clinical trial explanation" (as page type) with input value "Several clinical trials have investigated the benefits of hyperthermia for glioblastoma. A prospective randomized trial at UCSF combined hyperthermia with brachytherapy, showing a significant survival benefit. Other studies are exploring hyperthermia with gold nanoparticles for targeted heating, potentially increasing efficacy while minimizing damage to healthy tissues." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process. |
| Common Side Effects | Localized discomfort, potential damage to surrounding healthy tissue |
| OS without | Standard progression statistics for GBM |
| OS with | Extended survival reported in some clinical trials |
| PFS without | Standard progression statistics for GBM |
| PFS with | Improved progression-free survival in combination with other treatments |
| Usefulness Rating | 4 |
| Usefulness Explanation | Hyperthermia has shown potential in enhancing the effectiveness of radiation and chemotherapy, improving overall survival and progression-free survival rates in glioblastoma patients. |
| Toxicity Level | 3 |
| Toxicity Explanation | While hyperthermia can cause discomfort and risk damage to healthy tissues, these effects are generally manageable with precise control and monitoring. |
Notes: Hyperthermia treatment involves raising the temperature of tumor tissues to enhance the effectiveness of conventional cancer therapies such as radiation and chemotherapy. This method leverages heat to induce cellular stress and damage in cancer cells, making them more susceptible to other treatments. For glioblastoma, an aggressive brain tumor, hyperthermia has shown potential in improving treatment outcomes and extending patient survival.
Links: https://consultqd.clevelandclinic.org/turning-up-the-heat-on-glioblastoma-with-thermal-medicine/, https://brio-medical.com/hyperthermia-activation-in-treating-glioblastoma/, https://cancer.ucsf.edu/research/clinical-trials
From Ben Williams Book: Not specified
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