User contributions for Lazy

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For Lazy talk block log uploads logs
A user with 453 edits. Account created on 16 March 2024.
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24 March 2024

  • 06:1206:12, 24 March 2024 diff hist +3‎ Procarbazine ‎No edit summary
  • 06:1206:12, 24 March 2024 diff hist +481‎ N Bevacizumab (Avastin) ‎ Created page with "{{TreatmentInfo |drug_name=Bevacizumab (Avastin) |FDA_approval=Yes, for recurrent glioblastoma |used_for=Glioblastoma |clinical_trial_phase=Phase III |common_side_effects=Hypertension, proteinuria, and hemorrhage |OS_with=AVAglio trial: 16.8 months; RTOG trial: 15.7 months |usefulness_rating=4 |notes=Avastin improves PFS when used initially, but no significant benefit for overall survival compared to Avastin given at recurrence. |category=Other Chemotherapy and Cancer Dr..."
  • 06:1106:11, 24 March 2024 diff hist +404‎ N Procarbazine ‎ Created page with "{{TreatmentInfo |drug_name=Procarbazine |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Not specified |common_side_effects=Hematological toxicity, nausea, and neurological effects |OS_with=Not specified |usefulness_rating=3 |notes=Combination of Temodar and procarbazine showed a high percentage of tumor regressions, suggesting effectiveness. |category=Other Chemotherapy and Cancer Drugs"
  • 06:1006:10, 24 March 2024 diff hist +489‎ N Platinum Compounds ‎ Created page with "{{TreatmentInfo |drug_name=Platinum Compounds (Cisplatin) |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Various, including Phase II |common_side_effects=Nephrotoxicity, ototoxicity, and neurotoxicity |OS_with=Not specified |usefulness_rating=3 |notes=Combining Temodar with cisplatin has shown improved PFS-6 in recurrent tumors. A protocol combining Temodar, cisplatin, and etoposide reported median survival of 25 months. |category=Other Chemotherapy and C..."
  • 06:1006:10, 24 March 2024 diff hist +577‎ N BCNU (Carmustine) and Gliadel (Carmustine Wafers) ‎ Created page with "{{TreatmentInfo |drug_name=BCNU and Gliadel Wafers |FDA_approval=Yes |used_for=High-grade gliomas |clinical_trial_phase=Phase III (Europe for Gliadel) |common_side_effects=Low blood counts, pulmonary problems, infection, and seizures for Gliadel |OS_with=Gliadel: 13.9 months median survival; Combination with TMZ: Median survival ranges from 17 to 20.7 months |usefulness_rating=4 |notes=While Gliadel wafers alone offer modest improvement, combining them with the standard..."
  • 06:0906:09, 24 March 2024 diff hist +528‎ N CCNU (Lomustine) ‎ Created page with "{{TreatmentInfo |drug_name=CCNU (Lomustine) |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Phase 3 (Germany) |common_side_effects=Hematological toxicity, nausea, vomiting, and pulmonary toxicity |OS_with=23 months median survival, with 47% at 2 years |usefulness_rating=4 |notes=A combination of TMZ with CCNU showed promising results including a 5-year survival rate of 16% among a small patient cohort. MGMT methylation status significantly influenced outco..."
  • 06:0306:03, 24 March 2024 diff hist −18‎ Vitamin D ‎No edit summary
  • 06:0006:00, 24 March 2024 diff hist −19‎ Melatonin ‎No edit summary
  • 05:5705:57, 24 March 2024 diff hist +938‎ Main Page ‎No edit summary
  • 05:5505:55, 24 March 2024 diff hist +1,816‎ N Category:Antibody-Drug Conjugates and other protein-drug conjugates ‎ Created page with "== Introduction == Antibody-Drug Conjugates (ADCs) and other protein-drug conjugates represent a novel class of therapeutic agents in cancer treatment. These sophisticated therapies combine the specificity of antibodies or other proteins, which target specific markers on cancer cells, with potent cytotoxic drugs. This selective approach aims to minimize damage to healthy tissues while delivering powerful cancer-fighting agents directly to tumor cells. ADCs and similar c..."
  • 05:5305:53, 24 March 2024 diff hist +726‎ N MDNA55 ‎ Created page with "{{TreatmentInfo |drug_name=MDNA55 |FDA_approval=No |used_for=Recurrent malignant gliomas |clinical_trial_phase=Early phase trials |common_side_effects=Not specified in the provided text |OS_with=Not specified in the provided text |PFS_with=Not specified in the provided text |usefulness_rating=3 |notes=MDNA55, a fusion of IL-4 and Pseudomonas exotoxin A, targets cells with high IL-4R expression, common in tumor tissue. Preliminary data shows significant efficacy with a 56..."
  • 05:5205:52, 24 March 2024 diff hist +758‎ N ABT-414 ‎ Created page with "{{TreatmentInfo |drug_name=ABT-414 |FDA_approval=No |used_for=Targeting EGFR overexpressing glioblastoma cells |clinical_trial_phase=Phase 1 |common_side_effects=Eye toxicities, especially blurred vision |OS_with=Not reached at a median follow-up of 5.8 months |PFS_with=6.1 months for all patients, 5.9 months for EGFR amplified patients |usefulness_rating=2 |notes=ABT-414, an antibody-drug conjugate, selectively targets EGFR expressing tumor cells with minimal effects on..."

23 March 2024

21 March 2024

  • 05:4305:43, 21 March 2024 diff hist +1,334‎ N Garlic ‎ Created page with "{{TreatmentInfo |drug_name=Garlic (Allium sativum) |FDA_approval=No (Utilized as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in oncology, focusing on its cytotoxic effects against cancer cells and HDAC inhibition |clinical_trial_phase=Mostly preclinical, involving cell culture studies and some early-stage human research |common_side_effects=Generally well-tolerated; known side effects include gastrointestinal discomfort and..."
  • 05:3805:38, 21 March 2024 diff hist +1,774‎ N Fish oil ‎ Created page with "{{TreatmentInfo |drug_name=Fish Oil (Omega-3 Fatty Acids: EPA and DHA) |FDA_approval=No (Used as a dietary supplement; not specifically FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment for potential cytotoxic effects and enhancement of chemotherapy and radiation therapy efficacy |clinical_trial_phase=Clinical trials (e.g., advanced cancer study with cachexia, metastatic breast cancer Phase II trial, advanced non-small cell lung cancer..."
  • 05:3605:36, 21 March 2024 diff hist +1,456‎ N Ellagic acid ‎ Created page with "{{TreatmentInfo |drug_name=Ellagic Acid |FDA_approval=No (Utilized as a dietary component; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer prevention and treatment; noted for potential anti-cancer properties in laboratory studies |clinical_trial_phase=Preclinical and early clinical trials (e.g., prostate cancer study at UCLA) |common_side_effects=Not specifically documented; as a naturally occurring compound in fruits and nuts, it is genera..."
  • 05:3405:34, 21 March 2024 diff hist +1,345‎ N Curcumin ‎ Created page with "{{TreatmentInfo |drug_name=Curcumin |FDA_approval=No (Used as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment and prevention; also used for symptom management like dermatitis from radiotherapy |clinical_trial_phase=Preclinical studies and early clinical trials |common_side_effects=Generally well-tolerated; bioavailability issues are noted, but can be improved with piperine |OS_with=Not applicable; studies foc..."
  • 05:3205:32, 21 March 2024 diff hist +13‎ Melatonin ‎No edit summary
  • 05:3105:31, 21 March 2024 diff hist +13‎ Berberine ‎No edit summary
  • 05:3005:30, 21 March 2024 diff hist +12‎ Category:Nutraceuticals ‎No edit summary
  • 05:2105:21, 21 March 2024 diff hist −57‎ Cannabis ‎No edit summary
  • 05:1805:18, 21 March 2024 diff hist +1,653‎ N Cannabis ‎ Created page with "{{TreatmentInfo |drug_name=Cannabis and Cannabis-derived Products (e.g., Sativex) |FDA_approval=Sativex is approved in Canada and some European countries for neuropathic pain; cannabis itself is not FDA-approved for cancer treatment |used_for=Investigational use in cancer treatment, including glioblastoma, for its direct anti-cancer and anti-nausea effects |clinical_trial_phase=Preclinical studies and early clinical trials, including a notable trial with Sativex for glio..."
  • 05:1505:15, 21 March 2024 diff hist +1,331‎ N CBG ‎ Created page with "{{TreatmentInfo |drug_name=Cannabigerol (CBG) |FDA_approval=No (CBG is a cannabinoid compound under investigation; not FDA-approved for any condition) |used_for=Investigational use in cancer research for potential anti-tumor effects |clinical_trial_phase=Preclinical studies and early research |common_side_effects=Not specifically documented; cannabinoids are generally considered to have a favorable safety profile, but specific studies on CBG's side effects are limited |O..."
  • 05:1405:14, 21 March 2024 diff hist +1,290‎ N Sativex ‎ Created page with "{{TreatmentInfo |drug_name=Sativex (Nabiximols) |FDA_approval=Not FDA-approved in the United States; approved in several countries for spasticity due to multiple sclerosis |used_for=Investigational use in glioblastoma for potential direct anti-tumor effects and symptom management |clinical_trial_phase=Phase 2 clinical trial in 2021 indicated for glioblastoma |common_side_effects=Fatigue, dizziness, nausea, mouth irritation |OS_with=The 2021 trial reported an increase in..."
  • 05:1305:13, 21 March 2024 diff hist +1,291‎ N CBD ‎ Created page with "{{TreatmentInfo |drug_name=CBD (Cannabidiol) |FDA_approval=Yes, for specific epilepsy syndromes; not FDA-approved for cancer treatment |used_for=Investigational use in cancer treatment, including symptom management and potential anti-tumor effects |clinical_trial_phase=Preclinical studies and early human trials for cancer |common_side_effects=Tiredness, diarrhea, changes in appetite/weight; generally well-tolerated at doses used for epilepsy |OS_with=Not applicable; ongo..."
  • 05:0505:05, 21 March 2024 diff hist +1,257‎ N Metabolic therapy with Sodium R lipoate plus hydroxycitrate ‎ Created page with "{{TreatmentInfo |drug_name=Sodium R Lipoate and Hydroxycitrate (METABLOC) |FDA_approval=No (Used in investigational metabolic therapy for brain tumors) |used_for=Investigational use in brain tumor treatment, including primary and metastatic gliomas |clinical_trial_phase=Early clinical evaluation in a small case series |common_side_effects=Not specified in the provided information |OS_with=Varies; one GBM patient had a significant tumor shrinkage, others showed extended p..."
  • 05:0305:03, 21 March 2024 diff hist +1,191‎ N Limonene ‎ Created page with "{{TreatmentInfo |drug_name=Perillyl Alcohol/Limonene |FDA_approval=No (Under investigation for anti-cancer properties) |used_for=Investigational use in recurrent glioma treatment |clinical_trial_phase=Early-stage clinical trials, including studies in Brazil for recurrent glioma |common_side_effects=Gastro-intestinal side effects when administered orally; intranasal administration used to mitigate this |OS_with=Primary GBM: median survival of 5.9 months; Secondary GBM: me..."
  • 05:0105:01, 21 March 2024 diff hist +1,100‎ N GLA ‎ Created page with "{{TreatmentInfo |drug_name=Gamma-Linolenic Acid (GLA) |FDA_approval=No (Used as a dietary supplement) |used_for=Considered for cancer treatment support, but recommended to use omega-3 fatty acids from fish oil instead |clinical_trial_phase=Preclinical (rodent studies) |common_side_effects=Not specifically mentioned; dietary supplements like GLA are generally well-tolerated |OS_with=Not applicable; current recommendations favor omega-3 fatty acids for potential CNS benefi..."
  • 05:0005:00, 21 March 2024 diff hist +1,396‎ N PSK ‎ Created page with "{{TreatmentInfo |drug_name=PSK (Polysaccharide Krestin) and other polysaccharides |FDA_approval=No (Widely used in Japan as a standard cancer treatment component) |used_for=Over-the-Counter supplement for immune system enhancement and potential cancer treatment adjunct |clinical_trial_phase=Various, mainly in Japan for cancers like stomach, colon, and non-small cell lung cancer |common_side_effects=Not extensively documented; generally considered safe with potential for..."

20 March 2024

  • 06:0406:04, 20 March 2024 diff hist +1,293‎ N Trial of three drugs plus temodar ‎ Created page with "{{TreatmentInfo |drug_name=Combination of Repurposed Drugs plus Temodar |FDA_approval=Varies (individual drugs have separate FDA approvals for other conditions) |used_for=Investigational use in glioblastoma |clinical_trial_phase=Phase 1 and Phase 2 trials |common_side_effects=Varies based on the combination; potential for increased chemotherapy toxicity |OS_without=Standard treatment: median survival of 16.1 months |OS_with=Varies; one combination showed median survival..."
  • 06:0306:03, 20 March 2024 diff hist −5‎ Valproic acid ‎No edit summary
  • 06:0106:01, 20 March 2024 diff hist +1,167‎ N Valproic acid ‎ Created page with "{{TreatmentInfo |drug_name=Valproic Acid/Sodium Valproate (Depakote) |FDA_approval=Yes (for epilepsy) |used_for=Investigational use in glioblastoma for its HDAC inhibition properties |clinical_trial_phase=Retrospective studies and a prospective phase II trial |common_side_effects=Liver enzyme non-induction, potential increase in chemotherapy concentration, somnolence, constipation, potential liver toxicity |OS_without=Median survival with enzyme-inducing anticonvulsants:..."
  • 03:2603:26, 20 March 2024 diff hist +1,104‎ N Valcyte ‎ Created page with "{{TreatmentInfo |drug_name=Valganciclovir (Valcyte) |FDA_approval=Yes (for CMV infections) |used_for=Investigational use in glioblastoma due to potential effects against CMV positive tumors |clinical_trial_phase=Investigational, including early clinical trials |common_side_effects=Includes diarrhea, nausea, neutropenia, potential for increased risk of birth defects |OS_without=Median survival with standard treatment: 17.4 months |OS_with=Post-hoc analysis with at least s..."
  • 03:1803:18, 20 March 2024 diff hist +1,008‎ N Thalidomide ‎ Created page with "{{TreatmentInfo |drug_name=Thalidomide |FDA_approval=Yes (for leprosy and multiple myeloma) |used_for=Investigational use in various cancers due to antiangiogenic and immunomodulatory properties |clinical_trial_phase=Ongoing optimization of thalidomide analogues |common_side_effects=Deep vein thrombosis, peripheral neuropathy, constipation, somnolence, pyrexia, pain, teratogenicity |OS_with=Not specified; ongoing studies for cancer-specific outcomes |PFS_with=Not specifi..."
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