Letrozole: Difference between revisions

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(Created page with "{ "drug_name": "Letrozole", "FDA_approval": "Yes, for breast cancer; not FDA-approved for glioblastoma", "used_for": "Investigational use in glioblastoma based on preclinical studies", "clinical_trial_phase": "Preclinical studies and early research for glioblastoma", "common_side_effects": "Hot flashes, joint pain, nausea, fatigue, and risk of osteoporosis", "OS_with": "Not available; research in glioblastoma is still in early stages", "PFS_with": "Not avai...")
 
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{
{{TreatmentInfo
  "drug_name": "Letrozole",
|drug_name=Letrozole
  "FDA_approval": "Yes, for breast cancer; not FDA-approved for glioblastoma",
|FDA_approval=Yes (approved for breast cancer; not specifically approved for brain cancer yet)
  "used_for": "Investigational use in glioblastoma based on preclinical studies",
|used_for=Experimental for glioblastoma; approved for hormone receptor-positive breast cancer
  "clinical_trial_phase": "Preclinical studies and early research for glioblastoma",
|clinical_trial_phase=Phase 2
  "common_side_effects": "Hot flashes, joint pain, nausea, fatigue, and risk of osteoporosis",
|common_side_effects=Hot flashes, joint pain, nausea, increased risk of osteoporosis, fatigue
  "OS_with": "Not available; research in glioblastoma is still in early stages",
|OS_with=Not specified
  "PFS_with": "Not available; research in glioblastoma is still in early stages",
|OS_without=Not specified
  "usefulness_rating": "2 (based on early research potential, awaiting clinical trial outcomes for glioblastoma)",
|PFS_with=Not specified
  "toxicity_level": "2 (relatively low in the context of its approved use for breast cancer, with common manageable side effects)",
|PFS_without=Not specified
  "notes": "Letrozole, a drug commonly used in breast cancer treatment, has shown potential in preclinical studies for treating glioblastoma by targeting estrogen receptors, which are implicated in some glioblastoma cell growth. Further research, including clinical trials, is necessary to fully understand its efficacy and safety profile in glioblastoma patients.",
|usefulness_rating=3 - Under investigation
  "category": "Repurposed Drugs",
|toxicity_level=2.5
  "links": "https://braintomorrow.com/breast-cancer-drug-letrozole-glioblastoma/"
|notes=A collaborative study by the University of Cincinnati Cancer Center has initiated a Phase 2 trial to investigate the effectiveness of Letrozole in treating glioblastoma. This follows observations that certain breast cancer drugs, like Letrozole, which is used to treat hormone receptor-positive breast cancer, could be repurposed to inhibit the growth of glioblastoma cells by targeting estrogen receptors. The study is focused on understanding how Letrozole, when combined with standard therapy, affects the progression and treatment outcomes in glioblastoma patients.
}
|links=[University of Cincinnati article on Phase 2 brain tumor trial with Letrozole](https://www.uc.edu/news/articles/2024/02/collaborative-uc-cancer-center-team-opens-phase-2-brain-tumor-trial.html), [Brain Tomorrow's discussion on breast cancer drug Letrozole for glioblastoma](https://braintomorrow.com/breast-cancer-drug-letrozole-glioblastoma/)
|category=Experimental Treatments
}}

Revision as of 23:05, 26 March 2024

Property Information
Drug Name Letrozole
FDA Approval Yes (approved for breast cancer; not specifically approved for brain cancer yet)
Used for Experimental for glioblastoma; approved for hormone receptor-positive breast cancer
Clinical Trial Phase Phase 2
Clinical Trial Explanation Not specified
Common Side Effects Hot flashes, joint pain, nausea, increased risk of osteoporosis, fatigue
OS without Not specified
OS with Not specified
PFS without Not specified
PFS with Not specified
Usefulness Rating 3 - Under investigation
Usefulness Explanation Not specified
Toxicity Level 2.5
Toxicity Explanation Not specified

Notes: A collaborative study by the University of Cincinnati Cancer Center has initiated a Phase 2 trial to investigate the effectiveness of Letrozole in treating glioblastoma. This follows observations that certain breast cancer drugs, like Letrozole, which is used to treat hormone receptor-positive breast cancer, could be repurposed to inhibit the growth of glioblastoma cells by targeting estrogen receptors. The study is focused on understanding how Letrozole, when combined with standard therapy, affects the progression and treatment outcomes in glioblastoma patients.

Links: [University of Cincinnati article on Phase 2 brain tumor trial with Letrozole](https://www.uc.edu/news/articles/2024/02/collaborative-uc-cancer-center-team-opens-phase-2-brain-tumor-trial.html), [Brain Tomorrow's discussion on breast cancer drug Letrozole for glioblastoma](https://braintomorrow.com/breast-cancer-drug-letrozole-glioblastoma/)

From Ben Williams Book: Not specified

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