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Combined display of all available logs of Glioblastoma Treatments. You can narrow down the view by selecting a log type, the username (case-sensitive), or the affected page (also case-sensitive).

Logs
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  • 06:09, 24 March 2024 Lazy talk contribs created page CCNU (Lomustine) (Created page with "{{TreatmentInfo |drug_name=CCNU (Lomustine) |FDA_approval=Yes |used_for=Glioblastoma |clinical_trial_phase=Phase 3 (Germany) |common_side_effects=Hematological toxicity, nausea, vomiting, and pulmonary toxicity |OS_with=23 months median survival, with 47% at 2 years |usefulness_rating=4 |notes=A combination of TMZ with CCNU showed promising results including a 5-year survival rate of 16% among a small patient cohort. MGMT methylation status significantly influenced outco...")
  • 05:55, 24 March 2024 Lazy talk contribs created page Category:Antibody-Drug Conjugates and other protein-drug conjugates (Created page with "== Introduction == Antibody-Drug Conjugates (ADCs) and other protein-drug conjugates represent a novel class of therapeutic agents in cancer treatment. These sophisticated therapies combine the specificity of antibodies or other proteins, which target specific markers on cancer cells, with potent cytotoxic drugs. This selective approach aims to minimize damage to healthy tissues while delivering powerful cancer-fighting agents directly to tumor cells. ADCs and similar c...")
  • 05:53, 24 March 2024 Lazy talk contribs created page MDNA55 (Created page with "{{TreatmentInfo |drug_name=MDNA55 |FDA_approval=No |used_for=Recurrent malignant gliomas |clinical_trial_phase=Early phase trials |common_side_effects=Not specified in the provided text |OS_with=Not specified in the provided text |PFS_with=Not specified in the provided text |usefulness_rating=3 |notes=MDNA55, a fusion of IL-4 and Pseudomonas exotoxin A, targets cells with high IL-4R expression, common in tumor tissue. Preliminary data shows significant efficacy with a 56...")
  • 05:52, 24 March 2024 Lazy talk contribs created page ABT-414 (Created page with "{{TreatmentInfo |drug_name=ABT-414 |FDA_approval=No |used_for=Targeting EGFR overexpressing glioblastoma cells |clinical_trial_phase=Phase 1 |common_side_effects=Eye toxicities, especially blurred vision |OS_with=Not reached at a median follow-up of 5.8 months |PFS_with=6.1 months for all patients, 5.9 months for EGFR amplified patients |usefulness_rating=2 |notes=ABT-414, an antibody-drug conjugate, selectively targets EGFR expressing tumor cells with minimal effects on...")
  • 14:37, 23 March 2024 Lazy talk contribs created page Celebrex (Created page with "{{TreatmentInfo |drug_name=Celebrex (Celecoxib) and Other NSAIDs |FDA_approval=Yes (Celebrex is FDA-approved for arthritis and pain, but not specifically for cancer treatment) |used_for=Investigational use in cancer treatment due to anti-inflammatory, anti-angiogenic, and potential tumor growth inhibition properties |clinical_trial_phase=Early clinical trials and observational studies, including phase 2 trials combining Celebrex with conventional cancer treatments |commo...")
  • 14:33, 23 March 2024 Lazy talk contribs created page Thyroid Hormone T4 (Thyroxine) Suppression (Created page with "{{TreatmentInfo |drug_name=Thyroid Hormone T4 Suppression Therapy |FDA_approval=No (Used off-label for cancer treatment; specific regimen for cancer not FDA-approved) |used_for=Investigational use in cancer treatment, particularly in glioblastoma, based on observations of improved outcomes with hypothyroid status |clinical_trial_phase=Early clinical trials and case studies, including a phase 2 clinical trial in Israel (NCT02654041) |common_side_effects=Carefully monitore...")
  • 05:43, 21 March 2024 Lazy talk contribs created page Garlic (Created page with "{{TreatmentInfo |drug_name=Garlic (Allium sativum) |FDA_approval=No (Utilized as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in oncology, focusing on its cytotoxic effects against cancer cells and HDAC inhibition |clinical_trial_phase=Mostly preclinical, involving cell culture studies and some early-stage human research |common_side_effects=Generally well-tolerated; known side effects include gastrointestinal discomfort and...")
  • 05:38, 21 March 2024 Lazy talk contribs created page Fish oil (Created page with "{{TreatmentInfo |drug_name=Fish Oil (Omega-3 Fatty Acids: EPA and DHA) |FDA_approval=No (Used as a dietary supplement; not specifically FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment for potential cytotoxic effects and enhancement of chemotherapy and radiation therapy efficacy |clinical_trial_phase=Clinical trials (e.g., advanced cancer study with cachexia, metastatic breast cancer Phase II trial, advanced non-small cell lung cancer...")
  • 05:36, 21 March 2024 Lazy talk contribs created page Ellagic acid (Created page with "{{TreatmentInfo |drug_name=Ellagic Acid |FDA_approval=No (Utilized as a dietary component; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer prevention and treatment; noted for potential anti-cancer properties in laboratory studies |clinical_trial_phase=Preclinical and early clinical trials (e.g., prostate cancer study at UCLA) |common_side_effects=Not specifically documented; as a naturally occurring compound in fruits and nuts, it is genera...")
  • 05:34, 21 March 2024 Lazy talk contribs created page Curcumin (Created page with "{{TreatmentInfo |drug_name=Curcumin |FDA_approval=No (Used as a dietary supplement; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment and prevention; also used for symptom management like dermatitis from radiotherapy |clinical_trial_phase=Preclinical studies and early clinical trials |common_side_effects=Generally well-tolerated; bioavailability issues are noted, but can be improved with piperine |OS_with=Not applicable; studies foc...")
  • 05:18, 21 March 2024 Lazy talk contribs created page Cannabis (Created page with "{{TreatmentInfo |drug_name=Cannabis and Cannabis-derived Products (e.g., Sativex) |FDA_approval=Sativex is approved in Canada and some European countries for neuropathic pain; cannabis itself is not FDA-approved for cancer treatment |used_for=Investigational use in cancer treatment, including glioblastoma, for its direct anti-cancer and anti-nausea effects |clinical_trial_phase=Preclinical studies and early clinical trials, including a notable trial with Sativex for glio...")
  • 05:15, 21 March 2024 Lazy talk contribs created page CBG (Created page with "{{TreatmentInfo |drug_name=Cannabigerol (CBG) |FDA_approval=No (CBG is a cannabinoid compound under investigation; not FDA-approved for any condition) |used_for=Investigational use in cancer research for potential anti-tumor effects |clinical_trial_phase=Preclinical studies and early research |common_side_effects=Not specifically documented; cannabinoids are generally considered to have a favorable safety profile, but specific studies on CBG's side effects are limited |O...")
  • 05:14, 21 March 2024 Lazy talk contribs created page Sativex (Created page with "{{TreatmentInfo |drug_name=Sativex (Nabiximols) |FDA_approval=Not FDA-approved in the United States; approved in several countries for spasticity due to multiple sclerosis |used_for=Investigational use in glioblastoma for potential direct anti-tumor effects and symptom management |clinical_trial_phase=Phase 2 clinical trial in 2021 indicated for glioblastoma |common_side_effects=Fatigue, dizziness, nausea, mouth irritation |OS_with=The 2021 trial reported an increase in...")
  • 05:13, 21 March 2024 Lazy talk contribs created page CBD (Created page with "{{TreatmentInfo |drug_name=CBD (Cannabidiol) |FDA_approval=Yes, for specific epilepsy syndromes; not FDA-approved for cancer treatment |used_for=Investigational use in cancer treatment, including symptom management and potential anti-tumor effects |clinical_trial_phase=Preclinical studies and early human trials for cancer |common_side_effects=Tiredness, diarrhea, changes in appetite/weight; generally well-tolerated at doses used for epilepsy |OS_with=Not applicable; ongo...")
  • 05:05, 21 March 2024 Lazy talk contribs created page Metabolic therapy with Sodium R lipoate plus hydroxycitrate (Created page with "{{TreatmentInfo |drug_name=Sodium R Lipoate and Hydroxycitrate (METABLOC) |FDA_approval=No (Used in investigational metabolic therapy for brain tumors) |used_for=Investigational use in brain tumor treatment, including primary and metastatic gliomas |clinical_trial_phase=Early clinical evaluation in a small case series |common_side_effects=Not specified in the provided information |OS_with=Varies; one GBM patient had a significant tumor shrinkage, others showed extended p...")
  • 05:03, 21 March 2024 Lazy talk contribs created page Limonene (Created page with "{{TreatmentInfo |drug_name=Perillyl Alcohol/Limonene |FDA_approval=No (Under investigation for anti-cancer properties) |used_for=Investigational use in recurrent glioma treatment |clinical_trial_phase=Early-stage clinical trials, including studies in Brazil for recurrent glioma |common_side_effects=Gastro-intestinal side effects when administered orally; intranasal administration used to mitigate this |OS_with=Primary GBM: median survival of 5.9 months; Secondary GBM: me...")
  • 05:01, 21 March 2024 Lazy talk contribs created page GLA (Created page with "{{TreatmentInfo |drug_name=Gamma-Linolenic Acid (GLA) |FDA_approval=No (Used as a dietary supplement) |used_for=Considered for cancer treatment support, but recommended to use omega-3 fatty acids from fish oil instead |clinical_trial_phase=Preclinical (rodent studies) |common_side_effects=Not specifically mentioned; dietary supplements like GLA are generally well-tolerated |OS_with=Not applicable; current recommendations favor omega-3 fatty acids for potential CNS benefi...")
  • 05:00, 21 March 2024 Lazy talk contribs created page PSK (Created page with "{{TreatmentInfo |drug_name=PSK (Polysaccharide Krestin) and other polysaccharides |FDA_approval=No (Widely used in Japan as a standard cancer treatment component) |used_for=Over-the-Counter supplement for immune system enhancement and potential cancer treatment adjunct |clinical_trial_phase=Various, mainly in Japan for cancers like stomach, colon, and non-small cell lung cancer |common_side_effects=Not extensively documented; generally considered safe with potential for...")
  • 06:04, 20 March 2024 Lazy talk contribs created page Trial of three drugs plus temodar (Created page with "{{TreatmentInfo |drug_name=Combination of Repurposed Drugs plus Temodar |FDA_approval=Varies (individual drugs have separate FDA approvals for other conditions) |used_for=Investigational use in glioblastoma |clinical_trial_phase=Phase 1 and Phase 2 trials |common_side_effects=Varies based on the combination; potential for increased chemotherapy toxicity |OS_without=Standard treatment: median survival of 16.1 months |OS_with=Varies; one combination showed median survival...")
  • 06:01, 20 March 2024 Lazy talk contribs created page Valproic acid (Created page with "{{TreatmentInfo |drug_name=Valproic Acid/Sodium Valproate (Depakote) |FDA_approval=Yes (for epilepsy) |used_for=Investigational use in glioblastoma for its HDAC inhibition properties |clinical_trial_phase=Retrospective studies and a prospective phase II trial |common_side_effects=Liver enzyme non-induction, potential increase in chemotherapy concentration, somnolence, constipation, potential liver toxicity |OS_without=Median survival with enzyme-inducing anticonvulsants:...")
  • 03:26, 20 March 2024 Lazy talk contribs created page Valcyte (Created page with "{{TreatmentInfo |drug_name=Valganciclovir (Valcyte) |FDA_approval=Yes (for CMV infections) |used_for=Investigational use in glioblastoma due to potential effects against CMV positive tumors |clinical_trial_phase=Investigational, including early clinical trials |common_side_effects=Includes diarrhea, nausea, neutropenia, potential for increased risk of birth defects |OS_without=Median survival with standard treatment: 17.4 months |OS_with=Post-hoc analysis with at least s...")
  • 03:18, 20 March 2024 Lazy talk contribs created page Thalidomide (Created page with "{{TreatmentInfo |drug_name=Thalidomide |FDA_approval=Yes (for leprosy and multiple myeloma) |used_for=Investigational use in various cancers due to antiangiogenic and immunomodulatory properties |clinical_trial_phase=Ongoing optimization of thalidomide analogues |common_side_effects=Deep vein thrombosis, peripheral neuropathy, constipation, somnolence, pyrexia, pain, teratogenicity |OS_with=Not specified; ongoing studies for cancer-specific outcomes |PFS_with=Not specifi...")
  • 09:48, 19 March 2024 Lazy talk contribs created page Tamoxifen (Created page with "{{TreatmentInfo |drug_name=Tamoxifen |FDA_approval=Yes (for breast cancer treatment) |used_for=Investigational use in glioblastoma (GBM) treatment |clinical_trial_phase=Phase II clinical trials and retrospective studies |common_side_effects=Increased risk of blood clots, uterine cancer in women, impotence, and loss of libido in men, weight gain |OS_without=Not specified |OS_with=Varies; in gliomas, doses range from 160-240 mg per day showed tumor regression in 25% of pat...")
  • 09:45, 19 March 2024 Lazy talk contribs created page Proton Pump Inhibitors (Created page with "{{TreatmentInfo |drug_name=Proton Pump Inhibitors (e.g., Lansoprazole, Nexium) |FDA_approval=Yes (for heartburn and acid-related issues) |used_for=Investigational use in enhancing sensitivity of cancer cells to chemotherapy |clinical_trial_phase=Preclinical studies and observational studies in animals and humans |common_side_effects=Common PPI side effects include headache, nausea, diarrhea, abdominal pain, fatigue, and dizziness |OS_without=Not specified |OS_with=Studie...")
  • 09:41, 19 March 2024 Lazy talk contribs created page Methadone (Created page with "{{TreatmentInfo |drug_name=Methadone (D,L-methadone) |FDA_approval=Yes (for pain management and replacement therapy for addiction) |used_for=Investigational use in glioblastoma treatment for its chemosensitizing effects |clinical_trial_phase=Preclinical studies and a retrospective safety and tolerability study in glioma patients |common_side_effects=Nausea, constipation (obstipation); side effects commonly resolved after one month of therapy |OS_without=Not specified in...")
  • 09:35, 19 March 2024 Lazy talk contribs created page Keppra (Created page with "{{TreatmentInfo |drug_name=Keppra (Levetiracetam) |FDA_approval=Yes (as an anti-seizure medication, 1999) |used_for=Seizure prevention in brain tumor patients, potential sensitizer for glioblastoma cells to temozolomide chemotherapy |clinical_trial_phase=Retrospective studies and laboratory research |common_side_effects=Common side effects associated with Keppra include fatigue, dizziness, and mood changes, but it is generally well-tolerated in the context of brain tumor...")
  • 09:32, 19 March 2024 Lazy talk contribs created page Disulfiram (Created page with "{{TreatmentInfo |drug_name=Disulfiram (Antabuse) |FDA_approval=Yes (for preventing alcohol consumption) |used_for=Exploratory treatment for GBM in combination with temozolomide and potentially copper gluconate |clinical_trial_phase=Phase I pharmacodynamics trial at Washington University, ongoing research |common_side_effects=At higher doses: delirium and peripheral motor neuropathy; minimal toxicity when alcohol is not consumed |OS_without=Not specified |OS_with=Early re...")
  • 09:23, 19 March 2024 Lazy talk contribs created page Chloroquine (Created page with "{{TreatmentInfo |drug_name=Chloroquine and Hydroxychloroquine |FDA_approval=No (for glioblastoma treatment) |used_for=Glioblastoma, in combination with traditional chemotherapy agents |clinical_trial_phase=Reviewed in recent meta-analyses and studies |common_side_effects=Generally well-tolerated; specific studies noted minimal impact on adverse event incidence |OS_without=BCNU alone: median survival of 11 months |OS_with=Chloroquine with BCNU: median survival significant...")
  • 08:40, 19 March 2024 Lazy talk contribs created page Accutane (Created page with "{{TreatmentInfo |drug_name=Isotretinoin (Accutane) |FDA_approval=Yes (for acne treatment) |used_for=Neuroblastoma, severe acne |clinical_trial_phase=Used in various studies for cancer treatment |common_side_effects=Dry skin, liver problems, increased blood lipid levels, dry mouth, muscle or joint pain, sun sensitivity |OS_without=Not specified |OS_with=Not specified |PFS_without=Not specified |PFS_with=Not specified |usefulness_rating=3 |notes=Isotretinoin, a retinoid re...")
  • 08:34, 19 March 2024 Lazy talk contribs created page Vitamin D (Created page with "{{TreatmentInfo |drug_name=Vitamin D (Alfacalcidol, Paricalcitol, Cholecalciferol variants) |FDA_approval=No |used_for=Glioblastoma Multiforme (GBM), various types of cancer |clinical_trial_phase=Various studies, including recent meta-analyses and reviews |common_side_effects=Hypercalcemia at high doses of calcitriol; other forms generally safe |OS_without=Not explicitly detailed in recent reviews |OS_with=Recent meta-analyses suggest potential for improving cancer treat...")
  • 08:21, 19 March 2024 Lazy talk contribs created page Melatonin (Created page with "{{TreatmentInfo |drug_name=Melatonin |FDA_approval=No |used_for=Glioblastoma Multiforme (GBM), insomnia, jet lag |clinical_trial_phase=Mixed (Phase 2 and Phase 3 trials mentioned) |common_side_effects=No known toxic side effects |OS_without=Survival significantly greater in melatonin-treated subjects in small GBM study |OS_with=Increases efficacy of chemotherapy; significant survival benefit observed in various cancers |PFS_without=Not specified |PFS_with=Not specified |...")
  • 22:43, 17 March 2024 Lazy talk contribs created page Form:TreatmentInfo (Created page with "<noinclude> This is the "TreatmentInfo" form. To create a page with this form, enter the page name below; if a page with that name already exists, you will be sent to a form to edit that page. {{#forminput:form=TreatmentInfo}} </noinclude><includeonly> <div id="wikiPreview" style="display: none; padding-bottom: 25px; margin-bottom: 25px; border-bottom: 1px solid #AAAAAA;"></div> {{{for template|TreatmentInfo}}} {| class="formtable" ! !: | {{{field|!}}} |- ! Drug_name:...")
  • 22:06, 17 March 2024 Lazy talk contribs created page Berberine (Created page with "{{TreatmentInfo |drug_name=Berberine |FDA_approval=No |used_for=Glioblastoma Multiforme (GBM) |OS_without=Not explicitly mentioned; refer to specific studies for detailed metrics. |OS_with=Studies suggest enhancement of temozolomide efficacy in resistant GBM cases, potentially improving overall survival rates. |clinical_trial_phase=Pre-clinical (in vitro and in vivo studies) |common_side_effects=Not specifically listed for GBM treatment; generally well-tolerated but can...")
  • 22:03, 17 March 2024 Lazy talk contribs created page Category:Nutraceuticals (Created page with "= Nutraceuticals and Herbals = Oncologists routinely warn their patients not to use supplements, usually based on the belief that supplements that are anti-oxidants will interfere with both radiation and chemotherapy. While this issue is extremely complex, my own evaluation of the relevant evidence strongly disagrees with this opinion. [Introduction continues...] == List of Nutraceutical Treatments == {{#ask: Category:Nutraceuticals |?Has treatment name |?Has OS w...")
  • 20:50, 17 March 2024 Lazy talk contribs created page Cimetidine (Created page with "{{TreatmentInfo |drug_name=Cimetidine (Tagamet) |FDA_approval=Yes (for stomach conditions, not specifically approved for brain cancer yet) |used_for=Experimental for glioblastoma; approved for stomach acid reduction; noted use in colon cancer |mechanism_of_action=Decreases cell migration by affecting genes controlling cellular adhesion |clinical_trial_year=Recent (specific year not mentioned) |number_of_patients=N/A (mouse study) |median_survival=Substantially longer sur...")
  • 09:54, 16 March 2024 Lazy talk contribs created page Clomipramine (Created page with "{{TreatmentInfo |drug_name=Clomipramine |FDA_approval=Yes |used_for=Depression, Obsessive-compulsive disorder, GBM |category=Repurposed Drugs }}")
  • 09:45, 16 March 2024 Lazy talk contribs created page Category:RepurposedDrugs (Created page with "There are a large number of drugs that were developed initially for various different purposes that subsequent laboratory research demonstrated to have significant anti-cancer properties. Given these old drugs have been used for years, have well-defined toxicity profiles, and are generally cheaper due to being off-patent, they offer the possibility of augmenting the benefits of the current standard treatment without significant additional toxicity. However, because their...")
  • 09:44, 16 March 2024 Lazy talk contribs created page Category:Hormones (Created page with "Unlike traditional cancer chemotherapy, which kills cancer cells through directly cytotoxic mechanisms, a different approach may also prove to be effective: manipulation of the body’s balance of circulating hormones to achieve the most unwelcoming environment for the growth of tumors.")
  • 09:44, 16 March 2024 Lazy talk contribs created page Template:TreatmentInfo (Created page with "<noinclude> This template is for adding treatments. <includeonly> {| class="wikitable" |- ! Property !! Information |- | Drug Name || [[Has treatment name::{{{drug_name|}}}]] |- | FDA Approval || [[Is FDA approved::{{{FDA_approval|}}}]] |- | Used for || [[Used for condition::{{{used_for|}}}]] |- ... |} [[Category:{{{category|}}}]] </includeonly> </noinclude>")
  • 08:49, 16 March 2024 Maintenance script talk contribs created page Property:Owl:differentFrom (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page Property:Foaf:homepage (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page Property:Foaf:name (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page Property:Foaf:knows (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page MediaWiki:Smw import owl (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page MediaWiki:Smw import foaf (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page MediaWiki:Smw import skos (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page MediaWiki:Smw import schema (Semantic MediaWiki default vocabulary import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page smw/schema:Group:Predefined properties (Semantic MediaWiki group import)
  • 08:49, 16 March 2024 Maintenance script talk contribs created page smw/schema:Group:Schema properties (Semantic MediaWiki group import)
  • 08:24, 16 March 2024 MediaWiki default talk contribs created page Main Page
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