Sulforaphane
| Property | Information |
|---|---|
| Drug Name | Sulforaphane |
| FDA Approval | No (Used as a dietary supplement; not FDA-approved for cancer treatment) |
| Used for | Investigational use in cancer treatment, particularly in preclinical studies focusing on glioblastoma |
| Clinical Trial Phase | Preclinical studies |
| Clinical Trial Explanation | Sulforaphane is being studied in preclinical models for its potential as an anti-cancer agent against glioblastoma. Research focuses on its ability to inhibit histone deacetylase (HDAC) enzymes and modulate anti-inflammatory pathways, which could impact cancer stem cell viability and resistance.Property "Has clinical trial explanation" (as page type) with input value "Sulforaphane is being studied in preclinical models for its potential as an anti-cancer agent against glioblastoma. Research focuses on its ability to inhibit histone deacetylase (HDAC) enzymes and modulate anti-inflammatory pathways, which could impact cancer stem cell viability and resistance." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process. |
| Common Side Effects | Generally well-tolerated; possible digestive disturbances at high doses |
| OS without | Not specified |
| OS with | Not applicable; preclinical studies do not measure overall survival |
| PFS without | Not specified |
| PFS with | Not applicable; preclinical focus does not include progression-free survival metrics |
| Usefulness Rating | 3 |
| Usefulness Explanation | Sulforaphane has demonstrated potential in laboratory studies for inhibiting glioblastoma cell growth and influencing pathways critical for cancer stem cell survival and proliferation. Its impact on improving the efficacy of existing therapies for glioblastoma remains a significant area of ongoing research.Property "Has Usefulness Explanation" (as page type) with input value "Sulforaphane has demonstrated potential in laboratory studies for inhibiting glioblastoma cell growth and influencing pathways critical for cancer stem cell survival and proliferation. Its impact on improving the efficacy of existing therapies for glioblastoma remains a significant area of ongoing research." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process. |
| Toxicity Level | 1 |
| Toxicity Explanation | Sulforaphane is considered to have low toxicity and is generally well-tolerated as a dietary supplement. In high concentrations used in research settings, it may cause gastrointestinal discomfort, but these effects are minimal compared to conventional cancer therapies. |
Notes: Sulforaphane, a compound derived from cruciferous vegetables like broccoli, is studied for its potent anti-cancer properties, particularly its effects on enzyme inhibition and inflammation modulation. While its bioavailability and clinical efficacy specifically for glioblastoma treatment are under investigation, its known cellular mechanisms provide a promising basis for future clinical trials.
Links: * [Preclinical study on Sulforaphane in glioblastoma](https://pubmed.ncbi.nlm.nih.gov/?term=sulforaphane+glioblastoma)
- [Review of Sulforaphane's potential in cancer therapy](https://www.ncbi.nlm.nih.gov/pmc/articles/)
- [Sulforaphane and its effects on cancer cell apoptosis](https://www.cell.com/cancer-cell/home)
- [Sulforaphane in cancer prevention and therapy](https://cancerpreventionresearch.aacrjournals.org/)
From Ben Williams Book: Sulforaphane
This naturally occurring compound has shown promise in the laboratory for its ability to target and weaken cancer cells, particularly glioblastoma cells. It functions by inhibiting pathways that cancer cells use for growth and survival, potentially enhancing the responsiveness of these cells to treatments like chemotherapy and radiotherapy. Its role in cancer treatment, while still being evaluated, underscores the potential for using dietary compounds in a supportive or adjunctive therapy role.Property "Has original text" (as page type) with input value "Sulforaphane</br></br>This naturally occurring compound has shown promise in the laboratory for its ability to target and weaken cancer cells, particularly glioblastoma cells. It functions by inhibiting pathways that cancer cells use for growth and survival, potentially enhancing the responsiveness of these cells to treatments like chemotherapy and radiotherapy. Its role in cancer treatment, while still being evaluated, underscores the potential for using dietary compounds in a supportive or adjunctive therapy role." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
