GLA

Property	Information
Drug Name	Gamma-Linolenic Acid (GLA)
FDA Approval	No (Used as a dietary supplement)
Used for	Considered for cancer treatment support, but recommended to use omega-3 fatty acids from fish oil instead
Clinical Trial Phase	Preclinical (rodent studies)
Clinical Trial Explanation	Not specified
Common Side Effects	Not specifically mentioned; dietary supplements like GLA are generally well-tolerated
OS without	Not specified
OS with	Not applicable; current recommendations favor omega-3 fatty acids for potential CNS benefits
PFS without	Not specified
PFS with	Not applicable; emphasis on omega-3 fatty acids due to better CNS penetration and cost-effectiveness
Usefulness Rating	2
Usefulness Explanation	Not specified
Toxicity Level	Not specified
Toxicity Explanation	Not specified

Notes: Despite the potential of GLA as a dietary supplement, rodent studies indicate it does not effectively cross into the central nervous system or reach brain tumors after oral administration. Omega-3 fatty acids such as EPA and DHA, which are detectable in human cerebrospinal fluid and more likely to enter the CNS, are recommended instead. Omega-3s are also more cost-effective and share similar mechanisms of action to GLA.

From Ben Williams Book: Not specified

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