Resveratrol
| Property | Information |
|---|---|
| Drug Name | Resveratrol |
| FDA Approval | No (Used as a dietary supplement; not FDA-approved for cancer treatment) |
| Used for | Investigational use in cancer treatment and prevention; also studied for cardiovascular benefits and anti-aging properties |
| Clinical Trial Phase | Preclinical studies and early clinical trials |
| Clinical Trial Explanation | Resveratrol is being studied for its potential anti-cancer properties in preclinical and early clinical trials, focusing on its ability to modulate various signaling pathways involved in cell proliferation and survival. |
| Common Side Effects | Generally well-tolerated; some reports of gastrointestinal disturbances at high doses |
| OS without | Not specified |
| OS with | Not applicable; studies focus on biomolecular impacts rather than direct survival outcomes |
| PFS without | Not specified |
| PFS with | Not applicable; research has not extensively measured progression-free survival in cancer patients |
| Usefulness Rating | 3 |
| Usefulness Explanation | Resveratrol has shown potential in laboratory studies for modulating pathways that influence cancer cell growth and apoptosis, particularly in hormone-sensitive cancers. Its role in enhancing the efficacy of existing cancer therapies and in chemoprevention is currently under investigation.Property "Has Usefulness Explanation" (as page type) with input value "Resveratrol has shown potential in laboratory studies for modulating pathways that influence cancer cell growth and apoptosis, particularly in hormone-sensitive cancers. Its role in enhancing the efficacy of existing cancer therapies and in chemoprevention is currently under investigation." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process. |
| Toxicity Level | 1 |
| Toxicity Explanation | Resveratrol is generally well-tolerated with minimal side effects reported at dietary supplement levels. Higher doses used in clinical trials have occasionally resulted in gastrointestinal issues, but overall, it carries a low toxicity profile. As a dietary supplement, it has minimal regulatory oversight but is extensively studied for its broad pharmacological effects. |
Notes: Resveratrol, found in the skin of grapes and berries, exhibits properties that may inhibit cancer development and progression. It has been noted for its anti-inflammatory and antioxidant effects, which could play a role in its anti-cancer activities. While it has shown promise in laboratory studies, further research is necessary to establish its effectiveness and optimal use in clinical settings.
Links: * [ClinicalTrials.gov study on Resveratrol for various health outcomes](https://clinicaltrials.gov/ct2/results?cond=&term=resveratrol&cntry=&state=&city=&dist=)
- [Systematic review of the pharmacological effects of resveratrol in cancer and other diseases](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164842/)
- [Resveratrol and Cancer: Focus on in vivo evidence](https://www.cell.com/cell-metabolism/fulltext/S1550-4131(14)00062-0)
- [Resveratrol—Challenges in Translation to the Clinic—A Critical Discussion](https://www.mdpi.com/1422-0067/11/12/4745)
From Ben Williams Book: Resveratrol
This compound, commonly associated with red wine, has gained attention for its health benefits, including potential anti-cancer properties. It affects mechanisms like the inhibition of NF-kB and the activation of sirtuins that contribute to its anti-aging and anti-inflammatory effects. Although promising, its clinical efficacy in cancer treatment requires further validation.
Resveratrol's anti-cancer potential was highlighted in several studies where it was shown to modulate hormone receptor signaling pathways, making it of interest in hormone-driven cancers such as breast and prostate cancer. Like many supplements, its bioavailability is a concern, but ongoing research is addressing these challenges with novel delivery systems.Property "Has original text" (as page type) with input value "Resveratrol</br></br>This compound, commonly associated with red wine, has gained attention for its health benefits, including potential anti-cancer properties. It affects mechanisms like the inhibition of NF-kB and the activation of sirtuins that contribute to its anti-aging and anti-inflammatory effects. Although promising, its clinical efficacy in cancer treatment requires further validation.</br></br>Resveratrol's anti-cancer potential was highlighted in several studies where it was shown to modulate hormone receptor signaling pathways, making it of interest in hormone-driven cancers such as breast and prostate cancer. Like many supplements, its bioavailability is a concern, but ongoing research is addressing these challenges with novel delivery systems." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
