Clomipramine

Property	Information
Drug Name	Clomipramine (Chlorimipramine)
FDA Approval	Yes (for depression and obsessive-compulsive neuroses)
Used for	High-grade gliomas, including glioblastoma multiforme (GBM)
Clinical Trial Phase	Initial findings reported; further research needed
Clinical Trial Explanation	Not specified
Common Side Effects	Known for its general tolerability; specific studies on glioma treatment might reveal more details
OS without	Median survival with traditional treatments like BCNU alone reported at 11 months
OS with	When combined with chloroquine, median survival extended to 25-33 months according to early studies
PFS without	Not specified
PFS with	Improvement in PFS-6 when combined with traditional chemotherapy agents
Usefulness Rating	3
Usefulness Explanation	Not specified
Toxicity Level	Not specified
Toxicity Explanation	Not specified

Notes: Clomipramine, an antidepressant, has shown promise in treating high-grade gliomas by selectively depressing mitochondrial function in glioma cells, leading to apoptosis. Initial studies suggest potential efficacy in extending survival when combined with chemotherapy, though further detailed research is essential to validate these findings and explore mechanisms like autophagy inhibition.

From Ben Williams Book: Not specified

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