Accutane

Property	Information
Drug Name	Isotretinoin (Accutane)
FDA Approval	Yes (for acne treatment)
Used for	Neuroblastoma, severe acne
Clinical Trial Phase	Used in various studies for cancer treatment
Clinical Trial Explanation	Not specified
Common Side Effects	Dry skin, liver problems, increased blood lipid levels, dry mouth, muscle or joint pain, sun sensitivity
OS without	Not specified
OS with	Not specified
PFS without	Not specified
PFS with	Not specified
Usefulness Rating	3
Usefulness Explanation	Not specified
Toxicity Level	Not specified
Toxicity Explanation	Not specified

Notes: Isotretinoin, a retinoid related to vitamin A, controls cell growth by acting on specific nuclear receptors. It's used to treat severe acne and explored for cancer therapy potential, notably in neuroblastoma. It's important to avoid vitamin A supplements during treatment to prevent adverse interactions. Monitoring for liver function and blood lipid levels is advised due to possible side effects.

Links: [St. Jude’s comprehensive guide on isotretinoin](https://together.stjude.org/en-us/about-pediatric-cancer/treatment/medicines/isotretinoin.html)

From Ben Williams Book: Not specified

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