Clomipramine
| Property | Information |
|---|---|
| Drug Name | Clomipramine |
| FDA Approval | Yes |
| Used for | Depression, Obsessive-compulsive disorder, GBM |
| Clinical Trial Phase | Not specified |
| Clinical Trial Explanation | Not specified |
| Common Side Effects | Not specified |
| OS without | Not specified |
| OS with | Not specified |
| PFS without | Not specified |
| PFS with | Not specified |
| Usefulness Rating | Not rated |
| Usefulness Explanation | Not specified |
| Toxicity Level | Not specified |
| Toxicity Explanation | Not specified |
Notes: This old FDA-approved drug was first used for the treatment of depression, and now also for treatment of obsessive-compulsive neuroses. Its rationale as a treatment for gliomas is that it selectively depresses mitochondrial function in glioma cells while leaving normal cells unaffected, causing the glioma cells to undergo apoptosis (programmed cell death). Reported at the 2005 ASCO meeting (122) was a clinical trial evaluating the outcome of its use with 27 patients with high-grade gliomas (the distribution of GBMs vs. grade 3 tumors was not reported in the abstract, nor was the clinical history of the patients). Chlorimipramine was added to their conventional treatment with doses from 25 mg daily escalated to 150 mg daily. Median survival was 27 months; 20 of the 27 patients showed partial tumor regressions. This appears to be a promising new treatment, although additional testing with more detailed reporting of the results is clearly needed. An interesting sidelight on chlorimipramine is that laboratory research has shown that it strongly potentiates the toxicity of gleevec for glioma cells
From Ben Williams Book: Not specified
