Vitamin D

Property	Information
Drug Name	Vitamin D (Alfacalcidol, Paricalcitol, Cholecalciferol variants)
FDA Approval	No
Used for	Glioblastoma Multiforme (GBM), various types of cancer
Clinical Trial Phase	Various studies, including recent meta-analyses and reviews
Clinical Trial Explanation	Not specified
Common Side Effects	Hypercalcemia at high doses of calcitriol; other forms generally safe
OS without	Not explicitly detailed in recent reviews
OS with	Recent meta-analyses suggest potential for improving cancer treatment outcomes
PFS without	Not specified
PFS with	Not specified
Usefulness Rating	4
Usefulness Explanation	Not specified
Toxicity Level	2
Toxicity Explanation	A toxicity level of 2 for this treatment implies that it has a low toxicity level, meaning the common side effects observed are generally mild and tolerable. The main known side effect is a condition called Hypercalcemia, which is an excessive level of calcium in your blood, that occurs only at high doses of one type of Vitamin D variant. But, it's essential to follow recommended dosage and supplementation strategies for the best therapeutic benefits. The treatment lacks FDA approval currently, hence, it's important to have a conversation with your healthcare provider before starting any new supplement or treatment.

Notes: Recent reviews underscore Vitamin D's potential in cancer prevention and treatment, emphasizing its impact on biological mechanisms related to cancer regulation and its possible synergistic effects with chemo/immunotherapeutic drugs. The dosage and supplementation strategies are critical for optimizing its therapeutic benefits.

Links: * [The impact of vitamin D on cancer: A mini review - PubMed](https://pubmed.ncbi.nlm.nih.gov/37054849/)

• [Vitamin D supplementation and total cancer incidence and mortality - British Journal of Cancer](https://www.nature.com/articles/s41416-020-01188-1)

From Ben Williams Book: Not specified

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