Platinum Compounds
From Glioblastoma Treatments
| Property | Information |
|---|---|
| Drug Name | Platinum Compounds (Cisplatin) |
| FDA Approval | Yes |
| Used for | Glioblastoma |
| Clinical Trial Phase | Various, including Phase II |
| Clinical Trial Explanation | Not specified |
| Common Side Effects | Nephrotoxicity, ototoxicity, and neurotoxicity |
| OS without | Not specified |
| OS with | Not specified |
| PFS without | Not specified |
| PFS with | Not specified |
| Usefulness Rating | 3 |
| Usefulness Explanation | Not specified |
| Toxicity Level | 4 |
| Toxicity Explanation | The treatment with Platinum Compounds (Cisplatin) is considered relatively high in toxicity due to potential side effects like kidney damage (Nephrotoxicity), hearing loss (ototoxicity), and nervous system damage (neurotoxicity). It's important for patients to discuss these risks with their healthcare provider before starting therapy. A toxicity level of 4 out of 5 means this treatment carries significant risks, but it may be necessary for managing glioblastoma. |
Notes: Combining Temodar with cisplatin has shown improved PFS-6 in recurrent tumors. A protocol combining Temodar, cisplatin, and etoposide reported median survival of 25 months.
From Ben Williams Book: Not specified
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