Proton Radiation Therapy

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Property Information
Drug Name Proton Beam Therapy (PBT)
FDA Approval Yes
Used for Glioblastoma and other cancers
Clinical Trial Phase Ongoing research and clinical trials
Clinical Trial Explanation Not specified
Common Side Effects Radiation dermatitis, temporary alopecia, radiation otitis, radiation necrosis (more prevalent in PBT group)
OS without Data varies; traditional radiation therapies offer median OS of around 16-21 months for glioblastoma
OS with High-dose PBT showed a median OS of 65.6 months for patients with radiation necrosis, and 26.9 months for patients without radiation necrosis in specific studies
PFS without Standard radiation therapy PFS rates are lower compared to PBT
PFS with Improved PFS observed with PBT, specific rates vary by study
Usefulness Rating 4
Usefulness Explanation Not specified
Toxicity Level 3
Toxicity Explanation While acute radiation-related toxicities were equivalent to conventional radiation therapy, PBT has a higher prevalence of radiation necrosis, indicating a need for careful patient selection and management.



From Ben Williams Book: Proton Beam Therapy (PBT) represents a more targeted form of radiation therapy for glioblastoma, distinguished by its use of protons instead of traditional photons. This method allows for precise targeting of the tumor, minimizing damage to surrounding brain tissue. Research indicates that high-dose PBT can offer significant survival advantages over conventional radiation therapy, although it comes with a higher risk of radiation necrosis. Recent studies have explored the efficacy and safety of PBT, highlighting its potential to improve patient outcomes while also noting the importance of addressing associated toxic...Property "Has original text" (as page type) with input value "Proton Beam Therapy (PBT) represents a more targeted form of radiation therapy for glioblastoma, distinguished by its use of protons instead of traditional photons. This method allows for precise targeting of the tumor, minimizing damage to surrounding brain tissue. Research indicates that high-dose PBT can offer significant survival advantages over conventional radiation therapy, although it comes with a higher risk of radiation necrosis. Recent studies have explored the efficacy and safety of PBT, highlighting its potential to improve patient outcomes while also noting the importance of addressing associated toxic..." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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