VAL-083 (Dianhydrogalactitol): Difference between revisions

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(Created page with "{{TreatmentInfo |drug_name=VAL-083 (Dianhydrogalactitol) |FDA_approval=Approved in China for CML and lung cancer; not yet approved outside of China for GBM |used_for=Recurrent Glioblastoma Multiforme (GBM) with unmethylated MGMT promoter |clinical_trial_phase=Phase 2 (ongoing evaluation in GBM AGILE for various GBM subtypes) |common_side_effects=Myelosuppression, including neutropenia and lymphopenia; some instances of serious adverse events possibly related to VAL-083 |...")
 
(Updated category= to treatment_category= in TreatmentInfo template)
 
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|toxicity_explanation=The most common adverse event reported is myelosuppression, including instances of neutropenia and lymphopenia. A few patients experienced serious adverse events possibly related to VAL-083, indicating a moderate toxicity profile. Ongoing monitoring and management of these side effects are essential to minimize risks to patients.
|toxicity_explanation=The most common adverse event reported is myelosuppression, including instances of neutropenia and lymphopenia. A few patients experienced serious adverse events possibly related to VAL-083, indicating a moderate toxicity profile. Ongoing monitoring and management of these side effects are essential to minimize risks to patients.
|book_text=VAL-083 represents an innovative approach to treating recurrent GBM, leveraging a unique mechanism of action that differs from other alkylating agents. Its effectiveness in patients with specific genetic markers, such as an unmethylated MGMT promoter, underscores the importance of targeted genetic testing in guiding GBM treatment. Further studies are crucial to confirm these preliminary findings and fully establish VAL-083's therapeutic potential and safety profile in GBM treatment.
|book_text=VAL-083 represents an innovative approach to treating recurrent GBM, leveraging a unique mechanism of action that differs from other alkylating agents. Its effectiveness in patients with specific genetic markers, such as an unmethylated MGMT promoter, underscores the importance of targeted genetic testing in guiding GBM treatment. Further studies are crucial to confirm these preliminary findings and fully establish VAL-083's therapeutic potential and safety profile in GBM treatment.
|category=Other chemotherapy agents at recurrence
|treatment_category=Other chemotherapy agents at recurrence
}}
}}

Latest revision as of 10:41, 12 November 2024

Property Information
Drug Name VAL-083 (Dianhydrogalactitol)
FDA Approval Approved in China for CML and lung cancer; not yet approved outside of China for GBM
Used for Recurrent Glioblastoma Multiforme (GBM) with unmethylated MGMT promoter
Clinical Trial Phase Phase 2 (ongoing evaluation in GBM AGILE for various GBM subtypes)
Clinical Trial Explanation Not specified
Common Side Effects Myelosuppression, including neutropenia and lymphopenia; some instances of serious adverse events possibly related to VAL-083
OS without Historical mOS for similar patient population using lomustine is 7.2 months
OS with 8.0 months mOS observed in phase 2 trial for patients receiving treatment dose of 30 mg/m2/day
PFS without Not specified
PFS with Not fully established from available data
Usefulness Rating Pending further clinical trials
Usefulness Explanation Shows potential for treating recurrent GBM, especially in specific genetic profiles like unmethylated MGMT promoter. Comparative mOS suggests potential improvement over lomustine.
Toxicity Level 3
Toxicity Explanation The most common adverse event reported is myelosuppression, including instances of neutropenia and lymphopenia. A few patients experienced serious adverse events possibly related to VAL-083, indicating a moderate toxicity profile. Ongoing monitoring and management of these side effects are essential to minimize risks to patients.



From Ben Williams Book: VAL-083 represents an innovative approach to treating recurrent GBM, leveraging a unique mechanism of action that differs from other alkylating agents. Its effectiveness in patients with specific genetic markers, such as an unmethylated MGMT promoter, underscores the importance of targeted genetic testing in guiding GBM treatment. Further studies are crucial to confirm these preliminary findings and fully establish VAL-083's therapeutic potential and safety profile in GBM treatment.Property "Has original text" (as page type) with input value "VAL-083 represents an innovative approach to treating recurrent GBM, leveraging a unique mechanism of action that differs from other alkylating agents. Its effectiveness in patients with specific genetic markers, such as an unmethylated MGMT promoter, underscores the importance of targeted genetic testing in guiding GBM treatment. Further studies are crucial to confirm these preliminary findings and fully establish VAL-083's therapeutic potential and safety profile in GBM treatment." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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