Sulforaphane

Property	Information
Drug Name	Sulforaphane
FDA Approval	No (Used as a dietary supplement; not FDA-approved for cancer treatment)
Used for	Investigational use in cancer treatment, particularly in preclinical studies focusing on glioblastoma
Clinical Trial Phase	Preclinical studies
Clinical Trial Explanation	Sulforaphane is being studied in preclinical models for its potential as an anti-cancer agent against glioblastoma. Research focuses on its ability to inhibit histone deacetylase (HDAC) enzymes and modulate anti-inflammatory pathways, which could impact cancer stem cell viability and resistance.Property "Has clinical trial explanation" (as page type) with input value "Sulforaphane is being studied in preclinical models for its potential as an anti-cancer agent against glioblastoma. Research focuses on its ability to inhibit histone deacetylase (HDAC) enzymes and modulate anti-inflammatory pathways, which could impact cancer stem cell viability and resistance." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Common Side Effects	Generally well-tolerated; possible digestive disturbances at high doses
OS without	Not specified
OS with	Not applicable; preclinical studies do not measure overall survival
PFS without	Not specified
PFS with	Not applicable; preclinical focus does not include progression-free survival metrics
Usefulness Rating	3
Usefulness Explanation	Sulforaphane has demonstrated potential in laboratory studies for inhibiting glioblastoma cell growth and influencing pathways critical for cancer stem cell survival and proliferation. Its impact on improving the efficacy of existing therapies for glioblastoma remains a significant area of ongoing research.Property "Has Usefulness Explanation" (as page type) with input value "Sulforaphane has demonstrated potential in laboratory studies for inhibiting glioblastoma cell growth and influencing pathways critical for cancer stem cell survival and proliferation. Its impact on improving the efficacy of existing therapies for glioblastoma remains a significant area of ongoing research." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
Toxicity Level	1
Toxicity Explanation	Sulforaphane is considered to have low toxicity and is generally well-tolerated as a dietary supplement. In high concentrations used in research settings, it may cause gastrointestinal discomfort, but these effects are minimal compared to conventional cancer therapies.

Notes: Sulforaphane, a compound derived from cruciferous vegetables like broccoli, is studied for its potent anti-cancer properties, particularly its effects on enzyme inhibition and inflammation modulation. While its bioavailability and clinical efficacy specifically for glioblastoma treatment are under investigation, its known cellular mechanisms provide a promising basis for future clinical trials.

Links: * [Preclinical study on Sulforaphane in glioblastoma](https://pubmed.ncbi.nlm.nih.gov/?term=sulforaphane+glioblastoma)

• [Review of Sulforaphane's potential in cancer therapy](https://www.ncbi.nlm.nih.gov/pmc/articles/)
• [Sulforaphane and its effects on cancer cell apoptosis](https://www.cell.com/cancer-cell/home)
• [Sulforaphane in cancer prevention and therapy](https://cancerpreventionresearch.aacrjournals.org/)

From Ben Williams Book: Sulforaphane

This naturally occurring compound has shown promise in the laboratory for its ability to target and weaken cancer cells, particularly glioblastoma cells. It functions by inhibiting pathways that cancer cells use for growth and survival, potentially enhancing the responsiveness of these cells to treatments like chemotherapy and radiotherapy. Its role in cancer treatment, while still being evaluated, underscores the potential for using dietary compounds in a supportive or adjunctive therapy role.Property "Has original text" (as page type) with input value "Sulforaphane</br></br>This naturally occurring compound has shown promise in the laboratory for its ability to target and weaken cancer cells, particularly glioblastoma cells. It functions by inhibiting pathways that cancer cells use for growth and survival, potentially enhancing the responsiveness of these cells to treatments like chemotherapy and radiotherapy. Its role in cancer treatment, while still being evaluated, underscores the potential for using dietary compounds in a supportive or adjunctive therapy role." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Loading comments...