Tamoxifen: Difference between revisions
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(Created page with "{{TreatmentInfo |drug_name=Tamoxifen |FDA_approval=Yes (for breast cancer treatment) |used_for=Investigational use in glioblastoma (GBM) treatment |clinical_trial_phase=Phase II clinical trials and retrospective studies |common_side_effects=Increased risk of blood clots, uterine cancer in women, impotence, and loss of libido in men, weight gain |OS_without=Not specified |OS_with=Varies; in gliomas, doses range from 160-240 mg per day showed tumor regression in 25% of pat...") |
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|drug_name=Tamoxifen | |drug_name=Tamoxifen | ||
|FDA_approval=Yes (for breast cancer treatment) | |FDA_approval=Yes (for breast cancer treatment) | ||
|used_for=Investigational use in glioblastoma (GBM) | |used_for=Investigational use in glioblastoma (GBM) due to its inhibition of protein kinase C | ||
|clinical_trial_phase=Phase II clinical trials and retrospective studies | |clinical_trial_phase=Phase II clinical trials and retrospective studies for GBM | ||
|common_side_effects= | |common_side_effects=Blood clots, increased risk of uterine cancer in women, impotence and loss of libido in men, weight gain | ||
|OS_with=Data suggests tamoxifen may extend survival for certain glioblastoma patients, with specific outcomes depending on the study and patient demographics | |||
|OS_with= | |PFS_with=In studies, tamoxifen showed potential to improve progression-free survival for GBM patients under specific treatment regimens | ||
|PFS_with= | |||
|usefulness_rating=3 | |usefulness_rating=3 | ||
|notes= | |notes=While primarily known for breast cancer treatment, tamoxifen's role in GBM focuses on its protein kinase C inhibition, offering a novel therapeutic avenue. High-dosage use, distinct from breast cancer treatment, necessitates careful management of side effects. Early clinical evidence points to a potential for improved outcomes in GBM treatment, warranting further research to optimize use and identify responsive patient groups. | ||
|category=Repurposed Drugs | |category=Repurposed Drugs | ||
|links= | |links= | ||
|toxicity_level=3.5 | |||
|toxicity_explanation=Tamoxifen has been approved by FDA for breast cancer and while it is under investigation for glioblastoma, its high dosage use can lead to certain side effects. These include blood clots, potential risk of uterine cancer in women and impotence in men. Further, weight gain is also observed as a common side effect. Therefore, it is rated 3.5 in toxicity due to these common side effects and the potential serious health risks associated with its usage. | |||
}} | }} | ||
Latest revision as of 09:52, 27 March 2024
| Property | Information |
|---|---|
| Drug Name | Tamoxifen |
| FDA Approval | Yes (for breast cancer treatment) |
| Used for | Investigational use in glioblastoma (GBM) due to its inhibition of protein kinase C |
| Clinical Trial Phase | Phase II clinical trials and retrospective studies for GBM |
| Clinical Trial Explanation | Not specified |
| Common Side Effects | Blood clots, increased risk of uterine cancer in women, impotence and loss of libido in men, weight gain |
| OS without | Not specified |
| OS with | Data suggests tamoxifen may extend survival for certain glioblastoma patients, with specific outcomes depending on the study and patient demographics |
| PFS without | Not specified |
| PFS with | In studies, tamoxifen showed potential to improve progression-free survival for GBM patients under specific treatment regimens |
| Usefulness Rating | 3 |
| Usefulness Explanation | Not specified |
| Toxicity Level | 3.5 |
| Toxicity Explanation | Tamoxifen has been approved by FDA for breast cancer and while it is under investigation for glioblastoma, its high dosage use can lead to certain side effects. These include blood clots, potential risk of uterine cancer in women and impotence in men. Further, weight gain is also observed as a common side effect. Therefore, it is rated 3.5 in toxicity due to these common side effects and the potential serious health risks associated with its usage. |
Notes: While primarily known for breast cancer treatment, tamoxifen's role in GBM focuses on its protein kinase C inhibition, offering a novel therapeutic avenue. High-dosage use, distinct from breast cancer treatment, necessitates careful management of side effects. Early clinical evidence points to a potential for improved outcomes in GBM treatment, warranting further research to optimize use and identify responsive patient groups.
From Ben Williams Book: Not specified
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