]> 2026-04-12T02:22:43-07:00 CCNU (Lomustine) 0 en The toxicity level of CCNU is quite high due to several common side effects. Most notably, it can cause hematological toxicity, which means it can damage your blood cells and affect your body's ability to fight infections and clot properly. It can also cause nausea, vomiting, and pulmonary toxicity, which can lead to lung damage. On a scale from 1 to 5, with 5 being the most toxic, CCNU is rated as a 4. However, despite these side effects, the treatment showed promising results in a clinical trial. 2025-01-18T08:21:49Z 2460693.8484838 CCNU (Lomustine) 0 [2,"smw-datavalue-wikipage-property-invalid-title","Has original text","A report from Germany combined TMZ with CCNU (lomustine), the nitrosourea\ncomponent of the PCV combination (52). Patients (N=39) received CCNU on day 1 of\neach 6-week cycle, and TMZ on days 2-6. Eight patients received intensified doses of\nboth drugs, with somewhat better survival results (but with substantially increased\ntoxicity). For present purposes, the results of all patients are aggregated. Median survival\ntime was 23 months, and survival rates were 47%, 26%, 18%, and 16% at 2, 3, 4, and5\nyears, respectively. Four of the 39 patients had no recurrence at the 5-year mark. Only 23\nof the 39 patients were assessable for the status of the MGMT gene. Those with\nmethylated MGMT had a median survival of 34 months, while those with unmethylated\nMGMT had a median survival of only 12.5 months.\n\nThese results, including a 5-year survival rate of 16%, are among the best yet reported,\nalbeit with a relatively small number of patients. But it also should be appreciated that\npatients who suffered a recurrence received extensive salvage therapy of various types,\nwhich may have contributed substantially to survival time. The addition of CCNU to\nstandard therapy for newly diagnosed glioblastoma is currently being tested in a phase 3\ntrial in Germany."] CCNU (Lomustine)# ERRa3f62c6665776505f0db7c26c19aebf1 Has treatment name 102 en Has treatment name