]> 2026-04-12T05:42:19-07:00 Silibinin (an ingredient in Milk Thistle) 0 en Silibinin is considered to have few side effects, with gastrointestinal disturbances being the most common. 2025-01-18T08:24:09Z 2460693.8501042 Silibinin (an ingredient in Milk Thistle) 0 [2,"smw-datavalue-wikipage-property-invalid-title","Has original text","Silibinin (an ingredient of Milk Thistle)\n\nSilymarin is an extract from the milk thistle plant that has been used extensively in\nEurope as an antidote for liver toxicity, due to mushroom poisoning and overdoses of\ntylenol. Its active ingredient is a molecule called silibinin. Recently a great deal of\nlaboratory research has shown it to have anti-cancer effects, which recently have been\nreviewed (275). Like genistein and quercetin it is a tyrosine kinase inhibitor, but it\nappears to have multiple other effects, including the inhibition of the insulin-like growth\nfactor (IGF) that contributes to the development of chemoresistance (276) (see the section\non tamoxifen), and the inhibition of angiogenesis (277). It also inhibits the 5-\nlipoxygenase inflammatory pathway and suppresses nuclear factor kappa B, which is a\nprimary antagonist to apoptosis (278). It also appears to protect against common\nchemotherapy toxicities (279), while at the same time increasing the effectiveness of\n\ufffdchemotherapy."] Silibinin (an ingredient in Milk Thistle)# ERRa3f62c6665776505f0db7c26c19aebf1