User contributions for Lazy

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For Lazy talk block log uploads logs
A user with 559 edits. Account created on 16 March 2024.
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20 March 2024

  • 05:0105:01, 20 March 2024 diff hist +1,167‎ N Valproic acid ‎ Created page with "{{TreatmentInfo |drug_name=Valproic Acid/Sodium Valproate (Depakote) |FDA_approval=Yes (for epilepsy) |used_for=Investigational use in glioblastoma for its HDAC inhibition properties |clinical_trial_phase=Retrospective studies and a prospective phase II trial |common_side_effects=Liver enzyme non-induction, potential increase in chemotherapy concentration, somnolence, constipation, potential liver toxicity |OS_without=Median survival with enzyme-inducing anticonvulsants:..."
  • 02:2602:26, 20 March 2024 diff hist +1,104‎ N Valcyte ‎ Created page with "{{TreatmentInfo |drug_name=Valganciclovir (Valcyte) |FDA_approval=Yes (for CMV infections) |used_for=Investigational use in glioblastoma due to potential effects against CMV positive tumors |clinical_trial_phase=Investigational, including early clinical trials |common_side_effects=Includes diarrhea, nausea, neutropenia, potential for increased risk of birth defects |OS_without=Median survival with standard treatment: 17.4 months |OS_with=Post-hoc analysis with at least s..."
  • 02:1802:18, 20 March 2024 diff hist +1,008‎ N Thalidomide ‎ Created page with "{{TreatmentInfo |drug_name=Thalidomide |FDA_approval=Yes (for leprosy and multiple myeloma) |used_for=Investigational use in various cancers due to antiangiogenic and immunomodulatory properties |clinical_trial_phase=Ongoing optimization of thalidomide analogues |common_side_effects=Deep vein thrombosis, peripheral neuropathy, constipation, somnolence, pyrexia, pain, teratogenicity |OS_with=Not specified; ongoing studies for cancer-specific outcomes |PFS_with=Not specifi..."

19 March 2024

  • 08:5308:53, 19 March 2024 diff hist −80‎ Tamoxifen ‎No edit summary
  • 08:4808:48, 19 March 2024 diff hist +1,258‎ N Tamoxifen ‎ Created page with "{{TreatmentInfo |drug_name=Tamoxifen |FDA_approval=Yes (for breast cancer treatment) |used_for=Investigational use in glioblastoma (GBM) treatment |clinical_trial_phase=Phase II clinical trials and retrospective studies |common_side_effects=Increased risk of blood clots, uterine cancer in women, impotence, and loss of libido in men, weight gain |OS_without=Not specified |OS_with=Varies; in gliomas, doses range from 160-240 mg per day showed tumor regression in 25% of pat..."
  • 08:4508:45, 19 March 2024 diff hist +1,142‎ N Proton Pump Inhibitors ‎ Created page with "{{TreatmentInfo |drug_name=Proton Pump Inhibitors (e.g., Lansoprazole, Nexium) |FDA_approval=Yes (for heartburn and acid-related issues) |used_for=Investigational use in enhancing sensitivity of cancer cells to chemotherapy |clinical_trial_phase=Preclinical studies and observational studies in animals and humans |common_side_effects=Common PPI side effects include headache, nausea, diarrhea, abdominal pain, fatigue, and dizziness |OS_without=Not specified |OS_with=Studie..."
  • 08:4108:41, 19 March 2024 diff hist +1,446‎ N Methadone ‎ Created page with "{{TreatmentInfo |drug_name=Methadone (D,L-methadone) |FDA_approval=Yes (for pain management and replacement therapy for addiction) |used_for=Investigational use in glioblastoma treatment for its chemosensitizing effects |clinical_trial_phase=Preclinical studies and a retrospective safety and tolerability study in glioma patients |common_side_effects=Nausea, constipation (obstipation); side effects commonly resolved after one month of therapy |OS_without=Not specified in..."
  • 08:3508:35, 19 March 2024 diff hist +1,357‎ N Keppra ‎ Created page with "{{TreatmentInfo |drug_name=Keppra (Levetiracetam) |FDA_approval=Yes (as an anti-seizure medication, 1999) |used_for=Seizure prevention in brain tumor patients, potential sensitizer for glioblastoma cells to temozolomide chemotherapy |clinical_trial_phase=Retrospective studies and laboratory research |common_side_effects=Common side effects associated with Keppra include fatigue, dizziness, and mood changes, but it is generally well-tolerated in the context of brain tumor..."
  • 08:3208:32, 19 March 2024 diff hist +1,255‎ N Disulfiram ‎ Created page with "{{TreatmentInfo |drug_name=Disulfiram (Antabuse) |FDA_approval=Yes (for preventing alcohol consumption) |used_for=Exploratory treatment for GBM in combination with temozolomide and potentially copper gluconate |clinical_trial_phase=Phase I pharmacodynamics trial at Washington University, ongoing research |common_side_effects=At higher doses: delirium and peripheral motor neuropathy; minimal toxicity when alcohol is not consumed |OS_without=Not specified |OS_with=Early re..."
  • 08:2708:27, 19 March 2024 diff hist −103‎ Clomipramine ‎No edit summary
  • 08:2308:23, 19 March 2024 diff hist +1,748‎ N Chloroquine ‎ Created page with "{{TreatmentInfo |drug_name=Chloroquine and Hydroxychloroquine |FDA_approval=No (for glioblastoma treatment) |used_for=Glioblastoma, in combination with traditional chemotherapy agents |clinical_trial_phase=Reviewed in recent meta-analyses and studies |common_side_effects=Generally well-tolerated; specific studies noted minimal impact on adverse event incidence |OS_without=BCNU alone: median survival of 11 months |OS_with=Chloroquine with BCNU: median survival significant..."
  • 07:4007:40, 19 March 2024 diff hist +1,003‎ N Accutane ‎ Created page with "{{TreatmentInfo |drug_name=Isotretinoin (Accutane) |FDA_approval=Yes (for acne treatment) |used_for=Neuroblastoma, severe acne |clinical_trial_phase=Used in various studies for cancer treatment |common_side_effects=Dry skin, liver problems, increased blood lipid levels, dry mouth, muscle or joint pain, sun sensitivity |OS_without=Not specified |OS_with=Not specified |PFS_without=Not specified |PFS_with=Not specified |usefulness_rating=3 |notes=Isotretinoin, a retinoid re..."
  • 07:3407:34, 19 March 2024 diff hist +1,164‎ N Vitamin D ‎ Created page with "{{TreatmentInfo |drug_name=Vitamin D (Alfacalcidol, Paricalcitol, Cholecalciferol variants) |FDA_approval=No |used_for=Glioblastoma Multiforme (GBM), various types of cancer |clinical_trial_phase=Various studies, including recent meta-analyses and reviews |common_side_effects=Hypercalcemia at high doses of calcitriol; other forms generally safe |OS_without=Not explicitly detailed in recent reviews |OS_with=Recent meta-analyses suggest potential for improving cancer treat..."
  • 07:2507:25, 19 March 2024 diff hist +47‎ Main Page ‎ →‎Treatment Categories
  • 07:2307:23, 19 March 2024 diff hist +155‎ Template:TreatmentInfo ‎No edit summary
  • 07:2107:21, 19 March 2024 diff hist +1,113‎ N Melatonin ‎ Created page with "{{TreatmentInfo |drug_name=Melatonin |FDA_approval=No |used_for=Glioblastoma Multiforme (GBM), insomnia, jet lag |clinical_trial_phase=Mixed (Phase 2 and Phase 3 trials mentioned) |common_side_effects=No known toxic side effects |OS_without=Survival significantly greater in melatonin-treated subjects in small GBM study |OS_with=Increases efficacy of chemotherapy; significant survival benefit observed in various cancers |PFS_without=Not specified |PFS_with=Not specified |..."

18 March 2024

17 March 2024

16 March 2024

  • 08:5408:54, 16 March 2024 diff hist +144‎ N Clomipramine ‎ Created page with "{{TreatmentInfo |drug_name=Clomipramine |FDA_approval=Yes |used_for=Depression, Obsessive-compulsive disorder, GBM |category=Repurposed Drugs }}"
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