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| {{TreatmentInfo
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| |drug_name=Clomipramine
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| |FDA_approval=Yes
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| |used_for=Depression, Obsessive-compulsive disorder, GBM
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| |category=Repurposed Drugs
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| |notes=This old FDA-approved drug was first used for the treatment of depression, and now also
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| for treatment of obsessive-compulsive neuroses. Its rationale as a treatment for gliomas is
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| that it selectively depresses mitochondrial function in glioma cells while leaving normal
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| cells unaffected, causing the glioma cells to undergo apoptosis (programmed cell death).
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| Reported at the 2005 ASCO meeting (122) was a clinical trial evaluating the outcome of
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| its use with 27 patients with high-grade gliomas (the distribution of GBMs vs. grade 3
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| tumors was not reported in the abstract, nor was the clinical history of the patients).
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| Chlorimipramine was added to their conventional treatment with doses from 25 mg daily
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| escalated to 150 mg daily. Median survival was 27 months; 20 of the 27 patients showed
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| partial tumor regressions. This appears to be a promising new treatment, although
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| additional testing with more detailed reporting of the results is clearly needed. An
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| interesting sidelight on chlorimipramine is that laboratory research has shown that it
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| strongly potentiates the toxicity of gleevec for glioma cells
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| }}
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Latest revision as of 09:27, 27 March 2024
