Silibinin (an ingredient in Milk Thistle) - Revision history

Lazy at 08:24, 18 January 2025

2025-01-18T08:24:09Z

← Older revision		Revision as of 01:24, 18 January 2025
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	chemotherapy toxicities (279), while at the same time increasing the effectiveness of		chemotherapy toxicities (279), while at the same time increasing the effectiveness of
	�chemotherapy.		�chemotherapy.
	}}		\|overview=Silibinin, an active component of Silymarin derived from Milk Thistle, is primarily used for liver and biliary disorders and is being investigated as an adjunct in cancer treatment. While it has not yet received FDA approval, research suggests it may enhance chemotherapy efficacy and reduce toxicity, with minimal side effects primarily related to gastrointestinal disturbances.}}

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:37:40Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:37, 12 November 2024
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	\|usefulness_rating=Under investigation; shown to have anti-cancer effects in laboratory studies		\|usefulness_rating=Under investigation; shown to have anti-cancer effects in laboratory studies
	\|notes=Silibinin, the active component of Milk Thistle, has shown potential in stabilizing cellular membranes, stimulating detoxification pathways, and inhibiting cancer cell growth in laboratory studies. It has a long history of use for liver and biliary disorders. Clinical trials in cancer are limited but suggest a potential role in enhancing chemotherapy efficacy and reducing toxicity.		\|notes=Silibinin, the active component of Milk Thistle, has shown potential in stabilizing cellular membranes, stimulating detoxification pathways, and inhibiting cancer cell growth in laboratory studies. It has a long history of use for liver and biliary disorders. Clinical trials in cancer are limited but suggest a potential role in enhancing chemotherapy efficacy and reducing toxicity.
	\|~~category~~=Dietary Supplement		\|treatment_category=Dietary Supplement
	\|links=		\|links=
	* [Milk Thistle (PDQ®)–Health Professional Version - NCI](https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq)		* [Milk Thistle (PDQ®)–Health Professional Version - NCI](https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq)

Lazy at 21:57, 27 March 2024

2024-03-27T21:57:07Z

← Older revision		Revision as of 14:57, 27 March 2024
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	\|toxicity_level=Low		\|toxicity_level=Low
	\|toxicity_explanation=Silibinin is considered to have few side effects, with gastrointestinal disturbances being the most common.		\|toxicity_explanation=Silibinin is considered to have few side effects, with gastrointestinal disturbances being the most common.
	\|~~book_content~~=Silibinin (an ingredient of Milk Thistle)		\|book_text=Silibinin (an ingredient of Milk Thistle)

	Silymarin is an extract from the milk thistle plant that has been used extensively in		Silymarin is an extract from the milk thistle plant that has been used extensively in

Lazy: Created page with "{{TreatmentInfo |drug_name=Silibinin (Silymarin) |FDA_approval=No |used_for=Liver and biliary disorders, adjunct agent in cancer treatment |clinical_trial_phase=Investigated primarily in hepatitis and cirrhosis; small studies in cancers such as acute lymphoblastic leukemia, prostate cancer, breast cancer, head and neck cancer, and hepatocellular carcinoma |common_side_effects=Few reported; mainly gastrointestinal disturbances |OS_without=Not specified |OS_with=Not specif..."

2024-03-27T21:56:45Z

Created page with "{{TreatmentInfo |drug_name=Silibinin (Silymarin) |FDA_approval=No |used_for=Liver and biliary disorders, adjunct agent in cancer treatment |clinical_trial_phase=Investigated primarily in hepatitis and cirrhosis; small studies in cancers such as acute lymphoblastic leukemia, prostate cancer, breast cancer, head and neck cancer, and hepatocellular carcinoma |common_side_effects=Few reported; mainly gastrointestinal disturbances |OS_without=Not specified |OS_with=Not specif..."

New page

{{TreatmentInfo
|drug_name=Silibinin (Silymarin)
|FDA_approval=No
|used_for=Liver and biliary disorders, adjunct agent in cancer treatment
|clinical_trial_phase=Investigated primarily in hepatitis and cirrhosis; small studies in cancers such as acute lymphoblastic leukemia, prostate cancer, breast cancer, head and neck cancer, and hepatocellular carcinoma
|common_side_effects=Few reported; mainly gastrointestinal disturbances
|OS_without=Not specified
|OS_with=Not specified
|PFS_without=Not specified
|PFS_with=Not specified
|usefulness_rating=Under investigation; shown to have anti-cancer effects in laboratory studies
|notes=Silibinin, the active component of Milk Thistle, has shown potential in stabilizing cellular membranes, stimulating detoxification pathways, and inhibiting cancer cell growth in laboratory studies. It has a long history of use for liver and biliary disorders. Clinical trials in cancer are limited but suggest a potential role in enhancing chemotherapy efficacy and reducing toxicity.
|category=Dietary Supplement
|links=
* [Milk Thistle (PDQ®)–Health Professional Version - NCI](https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq)
|toxicity_level=Low
|toxicity_explanation=Silibinin is considered to have few side effects, with gastrointestinal disturbances being the most common.
|book_content=Silibinin (an ingredient of Milk Thistle)

Silymarin is an extract from the milk thistle plant that has been used extensively in
Europe as an antidote for liver toxicity, due to mushroom poisoning and overdoses of
tylenol. Its active ingredient is a molecule called silibinin. Recently a great deal of
laboratory research has shown it to have anti-cancer effects, which recently have been
reviewed (275). Like genistein and quercetin it is a tyrosine kinase inhibitor, but it
appears to have multiple other effects, including the inhibition of the insulin-like growth
factor (IGF) that contributes to the development of chemoresistance (276) (see the section
on tamoxifen), and the inhibition of angiogenesis (277). It also inhibits the 5-
lipoxygenase inflammatory pathway and suppresses nuclear factor kappa B, which is a
primary antagonist to apoptosis (278). It also appears to protect against common
chemotherapy toxicities (279), while at the same time increasing the effectiveness of
�chemotherapy.
}}