Metformin - Revision history

Lazy at 08:30, 18 January 2025

2025-01-18T08:30:39Z

← Older revision		Revision as of 01:30, 18 January 2025
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	* [Metformin and its potential therapeutic effects on glioblastoma](https://www.mdpi.com/journal/pharmaceuticals)		* [Metformin and its potential therapeutic effects on glioblastoma](https://www.mdpi.com/journal/pharmaceuticals)
	\|toxicity_explanation=Metformin is generally safe with a well-established profile. Most common side effects are related to the gastrointestinal system. The rare occurrence of lactic acidosis is a serious condition that requires medical attention. In the context of cancer treatment, monitoring and management of side effects are crucial.		\|toxicity_explanation=Metformin is generally safe with a well-established profile. Most common side effects are related to the gastrointestinal system. The rare occurrence of lactic acidosis is a serious condition that requires medical attention. In the context of cancer treatment, monitoring and management of side effects are crucial.
	}}		\|overview=Metformin, primarily an anti-diabetic medication, is under investigation for its potential anti-cancer properties in glioblastoma, with studies focusing on its effects on glioma stem cells and its ability to inhibit tumor growth. While it shows promise in preliminary research, further clinical trials are needed to confirm its efficacy and safety as a cancer treatment.}}

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:49:53Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:49, 12 November 2024
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	As a widely used diabetes medication, metformin has attracted interest for its potential anti-cancer effects, notably in glioblastoma. Research suggests that it may inhibit the growth of glioma stem cells, which are pivotal in tumor recurrence and resistance to treatment. By potentially disrupting the metabolic state of these cells, metformin could offer a novel approach to improving outcomes in glioblastoma patients.		As a widely used diabetes medication, metformin has attracted interest for its potential anti-cancer effects, notably in glioblastoma. Research suggests that it may inhibit the growth of glioma stem cells, which are pivotal in tumor recurrence and resistance to treatment. By potentially disrupting the metabolic state of these cells, metformin could offer a novel approach to improving outcomes in glioblastoma patients.

	\|~~category~~=Repurposed Drugs		\|treatment_category=Repurposed Drugs
	\|links=* [ClinicalTrials.gov list of metformin studies in glioblastoma](https://clinicaltrials.gov/ct2/results?cond=Glioblastoma&term=Metformin&cntry=&state=&city=&dist=)		\|links=* [ClinicalTrials.gov list of metformin studies in glioblastoma](https://clinicaltrials.gov/ct2/results?cond=Glioblastoma&term=Metformin&cntry=&state=&city=&dist=)
	* [Study on metformin's impact on glioma stem cells](https://www.ncbi.nlm.nih.gov/pubmed/)		* [Study on metformin's impact on glioma stem cells](https://www.ncbi.nlm.nih.gov/pubmed/)

Lazy at 17:55, 28 April 2024

2024-04-28T17:55:27Z

← Older revision		Revision as of 10:55, 28 April 2024
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	\|toxicity_level=2		\|toxicity_level=2
	\|notes=Metformin, primarily used for managing diabetes, is being explored for its potential to target metabolic pathways in cancer cells, including glioma stem cells. Its well-documented safety profile and widespread use make it a candidate for repurposing in oncology, with ongoing research needed to confirm its efficacy in glioblastoma treatment.		\|notes=Metformin, primarily used for managing diabetes, is being explored for its potential to target metabolic pathways in cancer cells, including glioma stem cells. Its well-documented safety profile and widespread use make it a candidate for repurposing in oncology, with ongoing research needed to confirm its efficacy in glioblastoma treatment.
	~~\|category=Repurposed Drugs~~
	~~\|book_text=Metformin~~

	As a widely used diabetes medication, metformin has attracted interest for its potential anti-cancer effects, notably in glioblastoma. Research suggests that it may inhibit the growth of glioma stem cells, which are pivotal in tumor recurrence and resistance to treatment. By potentially disrupting the metabolic state of these cells, metformin could offer a novel approach to improving outcomes in glioblastoma patients.		As a widely used diabetes medication, metformin has attracted interest for its potential anti-cancer effects, notably in glioblastoma. Research suggests that it may inhibit the growth of glioma stem cells, which are pivotal in tumor recurrence and resistance to treatment. By potentially disrupting the metabolic state of these cells, metformin could offer a novel approach to improving outcomes in glioblastoma patients.

			\|category=Repurposed Drugs
	\|links=* [ClinicalTrials.gov list of metformin studies in glioblastoma](https://clinicaltrials.gov/ct2/results?cond=Glioblastoma&term=Metformin&cntry=&state=&city=&dist=)		\|links=* [ClinicalTrials.gov list of metformin studies in glioblastoma](https://clinicaltrials.gov/ct2/results?cond=Glioblastoma&term=Metformin&cntry=&state=&city=&dist=)
	* [Study on metformin's impact on glioma stem cells](https://www.ncbi.nlm.nih.gov/pubmed/)		* [Study on metformin's impact on glioma stem cells](https://www.ncbi.nlm.nih.gov/pubmed/)

Lazy: Created page with "{{TreatmentInfo |drug_name=Metformin |FDA_approval=Yes (Approved for type 2 diabetes; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment, specifically studied for effects on glioblastoma and glioma stem cells |clinical_trial_phase=Preclinical studies and some clinical trials |clinical_trial_explanation=Metformin is under investigation for its potential anti-cancer properties in glioblastoma, particularly its effects on glioma stem ce..."

2024-04-28T17:53:35Z

Created page with "{{TreatmentInfo |drug_name=Metformin |FDA_approval=Yes (Approved for type 2 diabetes; not FDA-approved for cancer treatment) |used_for=Investigational use in cancer treatment, specifically studied for effects on glioblastoma and glioma stem cells |clinical_trial_phase=Preclinical studies and some clinical trials |clinical_trial_explanation=Metformin is under investigation for its potential anti-cancer properties in glioblastoma, particularly its effects on glioma stem ce..."

New page

{{TreatmentInfo
|drug_name=Metformin
|FDA_approval=Yes (Approved for type 2 diabetes; not FDA-approved for cancer treatment)
|used_for=Investigational use in cancer treatment, specifically studied for effects on glioblastoma and glioma stem cells
|clinical_trial_phase=Preclinical studies and some clinical trials
|clinical_trial_explanation=Metformin is under investigation for its potential anti-cancer properties in glioblastoma, particularly its effects on glioma stem cells. Studies focus on its ability to inhibit cell proliferation and induce apoptosis in cancerous cells.
|common_side_effects=Gastrointestinal upset, such as diarrhea and nausea; lactic acidosis (rare but serious)
|OS_with=Under investigation; some studies suggest potential for improved outcomes in cancer patients on metformin
|PFS_with=Under investigation; initial results indicate possible benefits in slowing disease progression
|usefulness_rating=3
|usefulness_explanation=Metformin has shown promise in laboratory and early clinical studies for impacting cancer cell metabolism and inhibiting growth, particularly in glioblastoma. Its effects on glioma stem cells may enhance susceptibility to conventional treatments and reduce tumor recurrence.
|toxicity_level=2
|notes=Metformin, primarily used for managing diabetes, is being explored for its potential to target metabolic pathways in cancer cells, including glioma stem cells. Its well-documented safety profile and widespread use make it a candidate for repurposing in oncology, with ongoing research needed to confirm its efficacy in glioblastoma treatment.
|category=Repurposed Drugs
|book_text=Metformin

As a widely used diabetes medication, metformin has attracted interest for its potential anti-cancer effects, notably in glioblastoma. Research suggests that it may inhibit the growth of glioma stem cells, which are pivotal in tumor recurrence and resistance to treatment. By potentially disrupting the metabolic state of these cells, metformin could offer a novel approach to improving outcomes in glioblastoma patients.

|links=* [ClinicalTrials.gov list of metformin studies in glioblastoma](https://clinicaltrials.gov/ct2/results?cond=Glioblastoma&term=Metformin&cntry=&state=&city=&dist=)
* [Study on metformin's impact on glioma stem cells](https://www.ncbi.nlm.nih.gov/pubmed/)
* [Review of metformin in cancer prevention and therapy](https://www.ncbi.nlm.nih.gov/pmc/articles/)
* [Metformin and its potential therapeutic effects on glioblastoma](https://www.mdpi.com/journal/pharmaceuticals)
|toxicity_explanation=Metformin is generally safe with a well-established profile. Most common side effects are related to the gastrointestinal system. The rare occurrence of lactic acidosis is a serious condition that requires medical attention. In the context of cancer treatment, monitoring and management of side effects are crucial.
}}