Melatonin - Revision history

Lazy at 20:37, 25 December 2024

2024-12-25T20:37:16Z

← Older revision		Revision as of 13:37, 25 December 2024
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	{{TreatmentInfo		{{TreatmentInfo
	\|drug_name=Melatonin		\|drug_name=Melatonin
	\| overview=Melatonin, a natural hormone known for regulating the sleep-wake cycle, has shown promise in cancer treatment, including glioblastoma. Clinical trials, particularly in Italy, suggest melatonin may boost survival rates when combined with chemotherapy, improve tumor regression, and reduce chemotherapy toxicity. While generally well-tolerated with no known toxic side effects, its potential as an adjuvant therapy continues to be explored, with ongoing research into its anti-cancer mechanisms and optimal usage.		\|overview=Melatonin, a natural hormone known for regulating the sleep-wake cycle, has shown promise in cancer treatment, including glioblastoma. Clinical trials, particularly in Italy, suggest melatonin may boost survival rates when combined with chemotherapy, improve tumor regression, and reduce chemotherapy toxicity. While generally well-tolerated with no known toxic side effects, its potential as an adjuvant therapy continues to be explored, with ongoing research into its anti-cancer mechanisms and optimal usage.
	\|FDA_approval=No		\|FDA_approval=No
	\|used_for=Jet lag, insomnia, various types of cancer including Glioblastoma Multiforme (GBM)		\|used_for=Jet lag, insomnia, various types of cancer including Glioblastoma Multiforme (GBM)

Lazy at 20:35, 25 December 2024

2024-12-25T20:35:23Z

← Older revision		Revision as of 13:35, 25 December 2024
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	{{TreatmentInfo		{{TreatmentInfo
	\|drug_name=Melatonin		\|drug_name=Melatonin
			\| overview=Melatonin, a natural hormone known for regulating the sleep-wake cycle, has shown promise in cancer treatment, including glioblastoma. Clinical trials, particularly in Italy, suggest melatonin may boost survival rates when combined with chemotherapy, improve tumor regression, and reduce chemotherapy toxicity. While generally well-tolerated with no known toxic side effects, its potential as an adjuvant therapy continues to be explored, with ongoing research into its anti-cancer mechanisms and optimal usage.
	\|FDA_approval=No		\|FDA_approval=No
	\|used_for=Jet lag, insomnia, various types of cancer including Glioblastoma Multiforme (GBM)		\|used_for=Jet lag, insomnia, various types of cancer including Glioblastoma Multiforme (GBM)

69.163.248.232 at 18:57, 12 November 2024

2024-11-12T18:57:14Z

← Older revision		Revision as of 11:57, 12 November 2024
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	* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.		* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.

	\|~~treatment_treatment_treatment_treatment_category~~=Hormones and Cancer Therapy		\|treatment_category=Hormones and Cancer Therapy
	\|links=https://www.mdpi.com/2073-4409/11/21/3467		\|links=https://www.mdpi.com/2073-4409/11/21/3467
	https://www.mdpi.com/2073-4409/9/3/599		https://www.mdpi.com/2073-4409/9/3/599

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:20:30Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:20, 12 November 2024
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	* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.		* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.

	\|~~treatment_treatment_treatment_category~~=Hormones and Cancer Therapy		\|treatment_treatment_treatment_treatment_category=Hormones and Cancer Therapy
	\|links=https://www.mdpi.com/2073-4409/11/21/3467		\|links=https://www.mdpi.com/2073-4409/11/21/3467
	https://www.mdpi.com/2073-4409/9/3/599		https://www.mdpi.com/2073-4409/9/3/599

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:15:54Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:15, 12 November 2024
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	* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.		* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.

	\|~~treatment_treatment_category~~=Hormones and Cancer Therapy		\|treatment_treatment_treatment_category=Hormones and Cancer Therapy
	\|links=https://www.mdpi.com/2073-4409/11/21/3467		\|links=https://www.mdpi.com/2073-4409/11/21/3467
	https://www.mdpi.com/2073-4409/9/3/599		https://www.mdpi.com/2073-4409/9/3/599

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:14:51Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:14, 12 November 2024
Line 67:		Line 67:
	* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.		* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.

	\|~~treatment_category~~=Hormones and Cancer Therapy		\|treatment_treatment_category=Hormones and Cancer Therapy
	\|links=https://www.mdpi.com/2073-4409/11/21/3467		\|links=https://www.mdpi.com/2073-4409/11/21/3467
	https://www.mdpi.com/2073-4409/9/3/599		https://www.mdpi.com/2073-4409/9/3/599

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:13:24Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:13, 12 November 2024
Line 67:		Line 67:
	* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.		* '''Modulation of Tumor Metabolism''': Affects energy production pathways in cancer cells, making them more susceptible to treatments.

	\|~~category~~=Hormones and Cancer Therapy		\|treatment_category=Hormones and Cancer Therapy
	\|links=https://www.mdpi.com/2073-4409/11/21/3467		\|links=https://www.mdpi.com/2073-4409/11/21/3467
	https://www.mdpi.com/2073-4409/9/3/599		https://www.mdpi.com/2073-4409/9/3/599

Lazy at 13:12, 13 August 2024

2024-08-13T13:12:54Z

← Older revision		Revision as of 06:12, 13 August 2024
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	Patients considering melatonin for GBM should consult with their oncologist. It’s essential to discuss the potential benefits and risks, considering that the most compelling evidence supports its use alongside chemotherapy. There might also be concerns about interactions with other medications and the appropriate dosage for anti-cancer effects, typically higher than those used for sleep disorders.		Patients considering melatonin for GBM should consult with their oncologist. It’s essential to discuss the potential benefits and risks, considering that the most compelling evidence supports its use alongside chemotherapy. There might also be concerns about interactions with other medications and the appropriate dosage for anti-cancer effects, typically higher than those used for sleep disorders.

	~~== Trial Results ==~~
	== GBM Study ==		== GBM Study ==
	* '''Trial''': Randomly assigned 30 GBM patients to radiation alone or radiation with 20 mg/day of melatonin.		* '''Trial''': Randomly assigned 30 GBM patients to radiation alone or radiation with 20 mg/day of melatonin.

Lazy at 13:12, 13 August 2024

2024-08-13T13:12:31Z

← Older revision		Revision as of 06:12, 13 August 2024
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	== Trial Results ==		== Trial Results ==
	= GBM Study =		== GBM Study ==
	* '''Trial''': Randomly assigned 30 GBM patients to radiation alone or radiation with 20 mg/day of melatonin.		* '''Trial''': Randomly assigned 30 GBM patients to radiation alone or radiation with 20 mg/day of melatonin.
	* '''Survival''':		* '''Survival''':
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	* '''Reference''': [Melatonin in the Treatment of Cancer (PDF)](https://www.acesototalhealth.com/wp-content/uploads/2020/07/Melatonin-in-the-tx-of-cancer.pdf).		* '''Reference''': [Melatonin in the Treatment of Cancer (PDF)](https://www.acesototalhealth.com/wp-content/uploads/2020/07/Melatonin-in-the-tx-of-cancer.pdf).

	= Larger Trials (Advanced Metastatic Cancer) =		== Larger Trials (Advanced Metastatic Cancer) ==
	* '''Trial''': 250 patients with advanced metastatic cancer of various types were randomized to chemotherapy alone or chemotherapy plus 20 mg of melatonin per day.		* '''Trial''': 250 patients with advanced metastatic cancer of various types were randomized to chemotherapy alone or chemotherapy plus 20 mg of melatonin per day.
	* '''Tumor Regression''':		* '''Tumor Regression''':
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	* '''Reference''': [Melatonin in Cancer Management: Progress and Promise](https://aacrjournals.org/cancerres/article/79/18/4827/636539/Melatonin-in-Cancer-Management-Progress-and-Promise).		* '''Reference''': [Melatonin in Cancer Management: Progress and Promise](https://aacrjournals.org/cancerres/article/79/18/4827/636539/Melatonin-in-Cancer-Management-Progress-and-Promise).

	= Metastatic Non-Small-Cell Lung Cancer Study =		== Metastatic Non-Small-Cell Lung Cancer Study ==
	* '''Trial''': 100 patients with metastatic non-small-cell lung cancer compared chemotherapy alone versus chemotherapy with melatonin.		* '''Trial''': 100 patients with metastatic non-small-cell lung cancer compared chemotherapy alone versus chemotherapy with melatonin.
	* '''Tumor Regression''':		* '''Tumor Regression''':
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	* '''Reference''': [Memorial Sloan Kettering Cancer Center](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/melatonin) and [Melatonin Research](https://www.melatonin-research.net/index.php/MR/article/view/45).		* '''Reference''': [Memorial Sloan Kettering Cancer Center](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/melatonin) and [Melatonin Research](https://www.melatonin-research.net/index.php/MR/article/view/45).

	= Aggregate Study (Lung, Colorectal, and Gastric Cancer) =		== Aggregate Study (Lung, Colorectal, and Gastric Cancer) ==
	* '''Patients''': 370 patients with lung cancer, colorectal cancer, and gastric cancer.		* '''Patients''': 370 patients with lung cancer, colorectal cancer, and gastric cancer.
	* '''Response Rate''':		* '''Response Rate''':
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	** Without Melatonin: 13% two-year survival rate.		** Without Melatonin: 13% two-year survival rate.

	= Ongoing Research =		== Ongoing Research ==
	* '''Research''': Mayo Clinic is investigating the use of melatonin to enhance glioblastoma treatment with temozolomide.		* '''Research''': Mayo Clinic is investigating the use of melatonin to enhance glioblastoma treatment with temozolomide.
	* '''Reference''': [Mayo Clinic](https://www.mayo.edu/research/labs/brain-tumor-stem-cell-research/research/melatonin-enhance-cancer-treatments).		* '''Reference''': [Mayo Clinic](https://www.mayo.edu/research/labs/brain-tumor-stem-cell-research/research/melatonin-enhance-cancer-treatments).

Lazy at 13:11, 13 August 2024

2024-08-13T13:11:40Z

← Older revision		Revision as of 06:11, 13 August 2024
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	Patients considering melatonin for GBM should consult with their oncologist. It’s essential to discuss the potential benefits and risks, considering that the most compelling evidence supports its use alongside chemotherapy. There might also be concerns about interactions with other medications and the appropriate dosage for anti-cancer effects, typically higher than those used for sleep disorders.		Patients considering melatonin for GBM should consult with their oncologist. It’s essential to discuss the potential benefits and risks, considering that the most compelling evidence supports its use alongside chemotherapy. There might also be concerns about interactions with other medications and the appropriate dosage for anti-cancer effects, typically higher than those used for sleep disorders.

	Trial Results		== Trial Results ==
	GBM Study		= GBM Study =
	* '''Trial''': Randomly assigned 30 GBM patients to radiation alone or radiation with 20 mg/day of melatonin.		* '''Trial''': Randomly assigned 30 GBM patients to radiation alone or radiation with 20 mg/day of melatonin.
	* '''Survival''':		* '''Survival''':
Line 27:		Line 27:
	* '''Reference''': [Melatonin in the Treatment of Cancer (PDF)](https://www.acesototalhealth.com/wp-content/uploads/2020/07/Melatonin-in-the-tx-of-cancer.pdf).		* '''Reference''': [Melatonin in the Treatment of Cancer (PDF)](https://www.acesototalhealth.com/wp-content/uploads/2020/07/Melatonin-in-the-tx-of-cancer.pdf).

	Larger Trials (Advanced Metastatic Cancer)		= Larger Trials (Advanced Metastatic Cancer) =
	* '''Trial''': 250 patients with advanced metastatic cancer of various types were randomized to chemotherapy alone or chemotherapy plus 20 mg of melatonin per day.		* '''Trial''': 250 patients with advanced metastatic cancer of various types were randomized to chemotherapy alone or chemotherapy plus 20 mg of melatonin per day.
	* '''Tumor Regression''':		* '''Tumor Regression''':
Line 37:		Line 37:
	* '''Reference''': [Melatonin in Cancer Management: Progress and Promise](https://aacrjournals.org/cancerres/article/79/18/4827/636539/Melatonin-in-Cancer-Management-Progress-and-Promise).		* '''Reference''': [Melatonin in Cancer Management: Progress and Promise](https://aacrjournals.org/cancerres/article/79/18/4827/636539/Melatonin-in-Cancer-Management-Progress-and-Promise).

	Metastatic Non-Small-Cell Lung Cancer Study		= Metastatic Non-Small-Cell Lung Cancer Study =
	* '''Trial''': 100 patients with metastatic non-small-cell lung cancer compared chemotherapy alone versus chemotherapy with melatonin.		* '''Trial''': 100 patients with metastatic non-small-cell lung cancer compared chemotherapy alone versus chemotherapy with melatonin.
	* '''Tumor Regression''':		* '''Tumor Regression''':
Line 47:		Line 47:
	* '''Reference''': [Memorial Sloan Kettering Cancer Center](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/melatonin) and [Melatonin Research](https://www.melatonin-research.net/index.php/MR/article/view/45).		* '''Reference''': [Memorial Sloan Kettering Cancer Center](https://www.mskcc.org/cancer-care/integrative-medicine/herbs/melatonin) and [Melatonin Research](https://www.melatonin-research.net/index.php/MR/article/view/45).

	Aggregate Study (Lung, Colorectal, and Gastric Cancer)		= Aggregate Study (Lung, Colorectal, and Gastric Cancer) =
	* '''Patients''': 370 patients with lung cancer, colorectal cancer, and gastric cancer.		* '''Patients''': 370 patients with lung cancer, colorectal cancer, and gastric cancer.
	* '''Response Rate''':		* '''Response Rate''':