Disulfiram - Revision history

Lazy at 08:16, 18 January 2025

2025-01-18T08:16:00Z

← Older revision		Revision as of 01:16, 18 January 2025
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	\|toxicity_level=2		\|toxicity_level=2
	\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.		\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		\|overview=Disulfiram (Antabuse), traditionally used to prevent alcohol consumption, is being explored as an adjunct treatment for glioblastoma (GBM) in combination with temozolomide and copper gluconate, showing potential efficacy in enhancing chemotherapy responses. Despite some side effects at higher doses, its low toxicity profile when alcohol is avoided makes it a promising candidate for repurposed drug strategies in cancer therapy.}}

69.163.248.232 at 18:58, 12 November 2024

2024-11-12T18:58:00Z

← Older revision		Revision as of 11:58, 12 November 2024
Line 11:		Line 11:
	\|usefulness_rating=3		\|usefulness_rating=3
	\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.		\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.
	\|~~treatment_treatment_treatment_treatment_category~~=Repurposed Drugs		\|treatment_category=Repurposed Drugs
	\|links=		\|links=
	\|toxicity_level=2		\|toxicity_level=2
	\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.		\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		}}

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:22:14Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:22, 12 November 2024
Line 11:		Line 11:
	\|usefulness_rating=3		\|usefulness_rating=3
	\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.		\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.
	\|~~treatment_treatment_treatment_category~~=Repurposed Drugs		\|treatment_treatment_treatment_treatment_category=Repurposed Drugs
	\|links=		\|links=
	\|toxicity_level=2		\|toxicity_level=2
	\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.		\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		}}

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:16:07Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:16, 12 November 2024
Line 11:		Line 11:
	\|usefulness_rating=3		\|usefulness_rating=3
	\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.		\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.
	\|~~treatment_treatment_category~~=Repurposed Drugs		\|treatment_treatment_treatment_category=Repurposed Drugs
	\|links=		\|links=
	\|toxicity_level=2		\|toxicity_level=2
	\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.		\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		}}

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:15:04Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:15, 12 November 2024
Line 11:		Line 11:
	\|usefulness_rating=3		\|usefulness_rating=3
	\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.		\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.
	\|~~treatment_category~~=Repurposed Drugs		\|treatment_treatment_category=Repurposed Drugs
	\|links=		\|links=
	\|toxicity_level=2		\|toxicity_level=2
	\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.		\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		}}

69.163.248.232: Updated category= to treatment_category= in TreatmentInfo template

2024-11-12T18:13:29Z

Updated category= to treatment_category= in TreatmentInfo template

← Older revision		Revision as of 11:13, 12 November 2024
Line 11:		Line 11:
	\|usefulness_rating=3		\|usefulness_rating=3
	\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.		\|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.
	\|~~category~~=Repurposed Drugs		\|treatment_category=Repurposed Drugs
	\|links=		\|links=
	\|toxicity_level=2		\|toxicity_level=2
	\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.		\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		}}

Lazy at 16:47, 27 March 2024

2024-03-27T16:47:46Z

← Older revision		Revision as of 09:47, 27 March 2024
Line 13:		Line 13:
	\|category=Repurposed Drugs		\|category=Repurposed Drugs
	\|links=		\|links=
			\|toxicity_level=2
			\|toxicity_explanation=Disulfiram shows a relatively low toxicity for treating Glioblastoma, especially when no alcohol is consumed. This means it could be a safer choice for treatment. Potential side effects like delirium and peripheral motor neuropathy were only reported at higher dosages. However, ongoing research is important to maximize therapeutic outcomes and minimize any potential side effects.
	}}		}}

Lazy: Created page with "{{TreatmentInfo |drug_name=Disulfiram (Antabuse) |FDA_approval=Yes (for preventing alcohol consumption) |used_for=Exploratory treatment for GBM in combination with temozolomide and potentially copper gluconate |clinical_trial_phase=Phase I pharmacodynamics trial at Washington University, ongoing research |common_side_effects=At higher doses: delirium and peripheral motor neuropathy; minimal toxicity when alcohol is not consumed |OS_without=Not specified |OS_with=Early re..."

2024-03-19T16:32:22Z

Created page with "{{TreatmentInfo |drug_name=Disulfiram (Antabuse) |FDA_approval=Yes (for preventing alcohol consumption) |used_for=Exploratory treatment for GBM in combination with temozolomide and potentially copper gluconate |clinical_trial_phase=Phase I pharmacodynamics trial at Washington University, ongoing research |common_side_effects=At higher doses: delirium and peripheral motor neuropathy; minimal toxicity when alcohol is not consumed |OS_without=Not specified |OS_with=Early re..."

New page

{{TreatmentInfo
|drug_name=Disulfiram (Antabuse)
|FDA_approval=Yes (for preventing alcohol consumption)
|used_for=Exploratory treatment for GBM in combination with temozolomide and potentially copper gluconate
|clinical_trial_phase=Phase I pharmacodynamics trial at Washington University, ongoing research
|common_side_effects=At higher doses: delirium and peripheral motor neuropathy; minimal toxicity when alcohol is not consumed
|OS_without=Not specified
|OS_with=Early results suggest potential efficacy in enhancing chemotherapy response; ongoing trials
|PFS_without=Not specified
|PFS_with=Initial results indicate a need for dosage optimization to balance efficacy and side effects
|usefulness_rating=3
|notes=Disulfiram, a drug traditionally used to prevent alcohol consumption, shows promise in GBM treatment through mechanisms such as blocking glycoprotein pumps and inhibiting MGMT enzyme and metalloproteinase activity. It's believed to inhibit the growth of cancer stem cells, a major source of treatment failures. Its anticancer effects may be potentiated by concurrent use of copper gluconate. Current trials are investigating optimal dosing and combination strategies to maximize therapeutic outcomes.
|category=Repurposed Drugs
|links=
}}