Editing Main Page (section)

====Platinum compounds====

An improvement in results relative to those obtained with Temodar alone has also been
reported when Temodar has been combined with cisplatin. In a pair of clinical studies
performed in Italy (61, 62) with patients with recurrent tumors, the PFS-6 was 34% and
35%. A treatment protocol with newly diagnosed patients that also seems to have
produced better results than Temodar as a single agent combined Temodar with both
cisplatin and etoposide (VP-16), given through the carotid artery (63). Cisplatin and
etoposide were given after surgery and continued for three cycles spaced every 3 weeks
apart, followed by the standard protocol of radiation plus low-dose Temodar, then
high-dose Temodar on the schedule of days 1-5 of every month. For 15 patients studied,
median survival was 25 months.